Abstract

This study reported a method for quickly detecting the moisture sorption of microneedle materials to predict the dissolving properties of the materials, and the flexibility of the microneedle materials can be preliminarily evaluated by bending strength test. Fifteen common microneedle matrix materials were selected, the dynamic vapor sorption analyzer (DVS) was used to obtain the moisture sorption data of different microneedle materials. Among the four types of microneedle materials, the dissolution rate within 5 min of hydroxypropyl methylcellulose (HPMC)was the slowest, while chondroitin sulfate (CS) was the fastest. By adding solubilizing agents to polyvinyl alcohol (PVA) microneedle, it was found that both the moisture sorption and the dissolving property of PVA are improved. The results proved that there was a correlation between the moisture sorption of microneedle materials and their dissolving properties in skin. The bending strength and hardness test results of model materials showed that the bending strength of flexible microneedle materials was generally higher than that of brittle microneedle materials, and the hardness of flexible materials could also be no less than that of brittle materials. Further investigation on the crystallization kinetics of microneedle materials under different relative humidity and the dissolving properties and mechanical properties of common microneedle matrix materials are needed.

摘要

本研究报道了一种快速检测微针材料吸湿性以预测材料溶解性能的方法，并可以通过弯曲强度试验初步评估微针材料的柔韧性。选取了15种常见的微针基质材料，利用动态蒸汽吸附分析仪（DVS）获得了不同微针材料的吸湿数据。四种微针材料中，羟丙基甲基纤维素（HPMC）5​​ min内溶解速度最慢，硫酸软骨素（CS）最快。通过在聚乙烯醇（PVA）微针中加入增溶剂，发现PVA的吸湿性和溶解性均得到改善。结果证明，微针材料的吸湿性与其在皮肤中的溶解性之间存在相关性。模型材料的弯曲强度和硬度测试结果表明，柔性微针材料的弯曲强度普遍高于脆性微针材料，柔性材料的硬度也可以不低于脆性材料。需要进一步研究微针材料在不同相对湿度下的结晶动力学以及常见微针基质材料的溶解性能和机械性能。模型材料的弯曲强度和硬度测试结果表明，柔性微针材料的弯曲强度普遍高于脆性微针材料，柔性材料的硬度也可以不低于脆性材料。需要进一步研究微针材料在不同相对湿度下的结晶动力学以及常见微针基质材料的溶解性能和机械性能。模型材料的弯曲强度和硬度测试结果表明，柔性微针材料的弯曲强度普遍高于脆性微针材料，柔性材料的硬度也可以不低于脆性材料。需要进一步研究微针材料在不同相对湿度下的结晶动力学以及常见微针基质材料的溶解性能和机械性能。