The EGO (Enforced Geometry Optimization) method provides a theoretical description of structural changes in molecules imposed by external forces. Brzyska and Wolinski present the application of EGO to predict enforced conformational changes in heterooligomers of the heteropolysaccharide nigeran, found in the cell wall of Aspergillus niger. Single‐molecule atomic force microscopy (AFM) can be used to study such structural changes; however, correct interpretation of AFM experimental data is often a difficult task. The authors find that the location of the sugar unit in the polysaccharide chain largely dictates the conformational properties and the results may help analyse AFM data in the future. (DOI: 10.1002/bip.23357)

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EGO（强制几何优化）方法提供了由外力施加的分子结构变化的理论描述。Brzyska和Wolinski介绍了EGO在预测黑曲霉细胞壁中发现的杂多糖黑尼日利亚杂合寡聚体中强制构象变化的应用。单分子原子力显微镜（AFM）可用于研究这种结构变化。但是，正确解释AFM实验数据通常是一项艰巨的任务。作者发现，糖单元在多糖链中的位置在很大程度上决定了构象特性，其结果可能有助于将来分析AFM数据。（DOI：10.1002 / bip.23357）