In this study, the development of our purpose‐made capacitively coupled contactless conductivity detection (C⁴D) for CE is reported. These systems have been employed as a simple, versatile, and cost‐effective analytical tool. CE‐C⁴D devices, whose principle is based on the control of the ion movements under an electrical field, can be constructed even with a modest financial budget and limited infrastructure. A featured application was developed for quality control of antimicrobial drugs using CE‐C⁴D, with most recent work on determination of aminoglycoside and glycopeptide antibiotics being communicated. For aminoglycosides, the development of CE‐C⁴D methods was adapted to two categories. The first one includes drugs (liquid or powder form) for intravenous injection, containing either amikacin, streptomycin, kanamycin A, or kanamycin B. The second one covers drugs for eye drops (liquid or ointment form), containing either neomycin, tobramycin, or polymyxin. The CE‐C⁴D method development was also made for determination of some popular glycopeptide antibiotics in Vietnam, including vancomycin and teicoplanin. The best detection limit achieved using the developed CE‐C⁴D methods was 0.5 mg/L. Good agreement between results from CE‐C⁴D and the confirmation method (HPLC‐ Photometric Diode Array ) was achieved, with their result deviations less than 8% and 13% for aminoglycoside and glycopeptide antibiotics, respectively.

中文翻译：

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具有专用毛细管电泳和非接触电导率检测功能的低成本，多功能分析工具：在越南抗生素质量控制中的应用。

在本研究中，报告了针对CE的专用电容耦合非接触电导率检测（C ⁴ D）的开发。这些系统已被用作简单，通用且经济高效的分析工具。CE‐C ⁴ D设备的原理是基于电场下离子运动的控制，即使在预算不高且基础设施有限的情况下也可以构建。开发了一个功能强大的应用程序，用于使用CE-C ⁴ D进行抗菌药物的质量控制，目前正在传达有关测定氨基糖苷和糖肽抗生素的最新工作。对于氨基糖苷，CE‐C ⁴的开发D方法适用于两类。第一种包括静脉注射的药物（液体或粉末形式），其中含有阿米卡星，链霉素，卡那霉素A或卡那霉素B。第二种药物包括滴眼剂（液体或软膏形式），其中含有新霉素，妥布霉素或多粘菌素。还开发了CE‐C ⁴ D方法来测定越南一些流行的糖肽抗生素，包括万古霉素和替考拉宁。使用发达的CE‐C ⁴ D方法获得的最佳检出限为0.5 mg / L。CE‐C ^4的结果之间具有良好的一致性达到了D和确认方法（HPLC-Photometric Diode Array），氨基糖苷和糖肽抗生素的结果偏差分别小于8％和13％。