Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in-vivo animal studies.,Journal of Biophotonics

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Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in-vivo animal studies.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-08-28 , DOI: 10.1002/jbio.202000267
Reem Hanna _{1,

2} , Snehal Dalvi _{1,

3} , Andrea Amaroli ₄ , Nicola De Angelis _{1,

5} , Stefano Benedicenti ₁

Affiliation

A present, photobiomodulation therapy (PBMT) effectiveness in enhancing bone regeneration in bone defects grafted with or without biomaterials is unclear. This systematic review (PROSPERO, ref. CRD 42019148959) aimed to critically appraise animal in vivo published data and present the efficacy of PBMT and its potential synergistic effects on grafted bone defects. MEDLINE, CCCT, Scopus, Science Direct, Google Scholar, EMBASE, EBSCO were searched, utilizing the following keywords: bone repair; low‐level laser therapy; LLLT; light emitting diode; LEDs; photobiomodulation therapy; in vivo animal studies, bone substitutes, to identify studies between 1994 and 2019. After applying the eligibility criteria, 38 papers included where the results reported according to “PRISMA.” The results revealed insufficient and incomplete PBM parameters, however, the outcomes with or without biomaterials have positive effects on bone healing. In conclusion, in vivo animal studies with a standardized protocol to elucidate the effects of PBMT on biomaterials are required initially prior to clinical studies.

中文翻译：

光生物调节对用骨替代物移植的骨缺损的影响：对体内动物研究的系统评价。

目前尚不清楚光生物调节疗法（PBMT）在增强使用或不使用生物材料移植的骨缺损中的骨再生的有效性。该系统评价（PROSPERO，ref。CRD 42019148959）旨在严格评估动物体内发表的数据，并提出PBMT的功效及其对移植骨缺损的潜在协同作用。使用以下关键字搜索了MEDLINE，CCCT，Scopus，Science Direct，Google Scholar，EMBASE，EBSCO。低水平激光治疗；LLLT；发光二极管; LED; 光生物调节疗法；体内动物研究（骨骼替代物）以识别1994年至2019年之间的研究。应用资格标准后，包括38篇论文，其中的结果根据“ PRISMA”进行报告。结果表明，PBM参数不足和不完整，但是，无论是否使用生物材料，结局都会对骨愈合产生积极影响。总之，在临床研究之前，首先需要进行具有标准化方案的体内动物研究，以阐明PBMT对生物材料的影响。

更新日期：2020-08-28

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