The new era of immune and reconstitution therapy of autoimmune disorders is ongoing. However, endocrine autoimmune diseases comprise a group of elaborating pathologies where the development of new treatment strategies remains slow. Substitution of the missing hormones is still standard practice, taking care of the devastating symptoms but not the cause of disease. As our knowledge of the genetic contribution to the aetiology of endocrine disorders increases and early diagnostic tools are available, it is now possible to identify persons at risk before they acquire full‐blown disease. This review summarizes current knowledge and treatment of endocrine autoimmune disorders, focusing on type 1 diabetes, Addison's disease, autoimmune thyroid diseases and primary ovarian insufficiency. We explore which new therapies might be used in the different stages of the disease, focus on legalized therapy and elaborate on the ongoing clinical studies for these diseases and the research front, before hypothesizing on the way ahead.

中文翻译：

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内分泌自身免疫性疾病治疗的新时代。

自身免疫性疾病的免疫和重组疗法的新纪元正在进行中。但是，内分泌自身免疫性疾病包括一组复杂的病理，其中新的治疗策略的开发仍很缓慢。替代缺失的激素仍是标准做法，要注意破坏性症状，但不能引起疾病。随着我们对内分泌疾病的病因学遗传贡献的知识的增加和可用的早期诊断工具，现在有可能在患上全面疾病之前识别高危人群。这篇综述总结了内分泌自身免疫性疾病的当前知识和治疗方法，重点是1型糖尿病，艾迪生氏病，自身免疫性甲状腺疾病和原发性卵巢功能不全。