It has been reported that EMMPRIN is involved in the regulation of immune response and the induction of MMPs production by fibroblasts. The aim of this study was to describe the intestinal gene expression and protein production of EMMPRIN, MMP23 and MMP10 in patients with ulcerative colitis (UC) and Crohn’s disease (CD) and compared them with a control group. Gene expression of EMMPRIN, MMP10 and MMP23B was measured by RT‐PCR. In order to determine EMMPRIN and MMP protein expression, colonic tissues were immunostained. The results of the study showed EMMPRIN gene expression was upregulated in rectal mucosa from active (a)UC versus aCD patients (P = .045), remission (r)CD group (P = .0009) and controls (P < .0001). We detected differences between rUC and aCD (P = .004), rCD (P < .0001) or control group (P < .0001). EMMPRIN showed a higher expression in mucosa (intraepithelial lymphocytes), submucosa and adventitia (endothelial cells) from aCD patients. MMP23 levels were increased in aUC and aCD compared to rUC and rCD and the control group (P = .0001). EMMPRIN+/MMP23+─expressing cells were localized mainly in mucosa, muscular and adventitia from active UC patients. MMP10 gene expression was increased in aUC versus CD patients and the control group (P = .0001). MMP10 gene expression is associated with inflammation in UC patients (P = .0001, r² = .585). EMMPRIN+/MMP10+─producing cells were found mainly in all intestinal layers and perivascular inflammatory infiltrates from aUC patients. In conclusion, EMMPRIN, MMP23 and MMP10 were upregulated in patients with active UC versus remission UC , CD and control groups suggesting that, they are involved in the inflammatory process.

中文翻译：

---

炎症性肠病中细胞外基质金属蛋白酶诱导剂（EMMPRIN）和MMP10，MMP23表达的增加：横断面研究。

据报道，EMMPRIN参与免疫应答的调节和成纤维细胞对MMP产生的诱导。这项研究的目的是描述溃疡性结肠炎（UC）和克罗恩氏病（CD）患者的肠道基因表达和EMMPRIN，MMP23和MMP10的蛋白质产生并将它们与对照组进行比较。通过RT-PCR测量EMMPRIN，MMP10和MMP23B的基因表达。为了确定EMMPRIN和MMP蛋白表达，对结肠组织进行了免疫染色。研究结果显示，活动性（a）UC相对于aCD患者（P  = .045），缓解（r）CD组（P  = .0009）和对照组（P  <.0001）的直肠黏膜中EMMPRIN基因表达上调。。我们检测到rUC和aCD之间的差异（P  = .004），rCD（P  <.0001）或对照组（P  <.0001）。EMMPRIN在aCD患者的黏膜（上皮内淋巴细胞），黏膜下层和外膜（内皮细胞）中表达较高。与rUC和rCD和对照组相比，aUC和aCD中的MMP23水平升高（P  = .0001）。EMMPRIN + / MMP23 +表达细胞主要位于活跃的UC患者的粘膜，肌肉和外膜中。与CD患者和对照组相比，aUC中MMP10基因表达增加（P  = .0001）。MMP10基因表达与UC患者的炎症有关（P  = .0001，r ² = .585）。产生EMMPRIN + / MMP10 +的细胞主要存在于aUC患者的所有肠层和血管周围炎性浸润物中。总之，活动性UC患者相对于缓解性UC，CD和对照组，EMMPRIN，MMP23和MMP10被上调，表明它们参与了炎症过程。