The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females.

中文翻译：

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次黄嘌呤磷酸核糖基转移酶（HPRT）缺乏与雌性大鼠的生育力受损有关。

嘌呤次黄嘌呤在调节卵母细胞成熟和早期胚胎发育中起重要作用。次黄嘌呤磷酸核糖基转移酶（HPRT）回收次黄嘌呤以生成核苷酸合成和关键代谢产物的底物，在这里我们证明HPRT缺乏会破坏早期胚胎发育并引起雌性不育。