In late 2019, SARS-CoV-2 started to spread throughout the world causing the COVID-19 that has taken a considerable number of lives. Results obtained from several investigations have explained the virus origin, pathogenicity, and transmission. Similar to SARS coronavirus, the pulmonary angiotensin converting enzyme (ACE) 2 was introduced as the virus receptor for entering the cell. An increased body of epidemiological and clinical evidences has shown modulating effects of vitamin D in lung injuries through several mechanisms. Several clinical symptoms as well as molecular factors have shown to be related to the disease transmission and severity. In this study, vitamin D, ACE concentrations, and neutrophil to lymphocyte ratio (NLR) were measured in patients with confirmed COVID-19 in comparison with control group. Results demonstrated significant alterations in vitamin D and ACE levels as well as NLR in the patients’ group. Contribution of those factors with the prognosis and severity of the disease has been shown.

2019 年底，SARS-CoV-2 开始在世界范围内传播，导致 COVID-19 夺走了相当多的人的生命。多项调查的结果解释了病毒的起源、致病性和传播。与SARS冠状病毒类似，引入肺血管紧张素转换酶（ACE）2作为进入细胞的病毒受体。越来越多的流行病学和临床证据表明维生素 D 通过多种机制对肺损伤具有调节作用。一些临床症状以及分子因素已被证明与疾病传播和严重程度有关。在这项研究中，测量了确诊的 COVID-19 患者的维生素 D、ACE 浓度和中性粒细胞与淋巴细胞比率 (NLR)，并与对照组进行比较。结果表明，患者组中维生素 D 和 ACE 水平以及 NLR 发生显着变化。已显示这些因素对疾病的预后和严重程度的贡献。