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Mosquitocidal activity of p,p’-difluoro-diphenyl-trichloroethane (DFDT)
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.pestbp.2020.104686
Edmund J Norris 1 , Fabien Demares 1 , Xiaolong Zhu 2 , Jeffrey R Bloomquist 1
Affiliation  

New insecticides are urgently needed for the control of arthropod vectors of public health diseases. As resistance to many insecticides used for the control of public health pests is ubiquitous, all available chemistries should be evaluated for their potential to effectively control both insecticide-susceptible and insecticide-resistant strains of mosquitoes. This study aimed to evaluate p-p'-difluoro-diphenyl-trichloroethane (DFDT) as a mosquito control technology and relate its activity to that of DDT. We found that topical DFDT was significantly less toxic than DDT to both pyrethroid-susceptible and pyrethroid-resistant strains of Anopheles gambiae and Aedes aegypti. Direct nervous system recording from Drosophila melanogaster CNS demonstrated that DFDT is approximately 10-times less potent than DDT at blocking nerve firing, which may explain its relatively lower toxicity. DFDT was shown to be at least 4500 times more vapor-active than DDT, with an LC50 in a vapor toxicity screening assay of 2.2 μg/cm2. Resistance to DFDT was assessed in two mosquito strains that possess target-site mutations in the voltage-gated sodium channel and upregulated metabolic activity. Resistance ratios for Akdr (An. gambiae) and Puerto Rico (Ae. aegypti) strains were 9.2 and 12.2, respectively. Overall, this study demonstrates that DFDT is unlikely to be a viable public health vector control insecticide.

中文翻译:


对,对'-二氟二苯基三氯乙烷 (DFDT) 的杀蚊活性



迫切需要新的杀虫剂来控制公共卫生疾病的节肢动物媒介。由于对许多用于控制公共卫生害虫的杀虫剂的抗药性普遍存在,因此应评估所有可用的化学物质有效控制对杀虫剂敏感和对杀虫剂具有抗性的蚊子品系的潜力。本研究旨在评估对-对'-二氟二苯基三氯乙烷 (DFDT) 作为一种蚊虫控制技术,并将其活性与 DDT 的活性联系起来。我们发现,对于拟除虫菊酯敏感和拟除虫菊酯耐药菌株冈比亚按蚊和埃及伊蚊来说,外用 DFDT 的毒性明显低于 DDT。果蝇中枢神经系统的直接神经系统记录表明,DFDT 在阻断神经放电方面的效力比 DDT 低约 10 倍,这可能解释了其毒性相对较低的原因。 DFDT 的蒸气活性至少是 DDT 的 4500 倍,蒸气毒性筛选试验中的 LC50 为 2.2 μg/cm2。在两种蚊子品系中评估了对 DFDT 的抗性,这两种蚊子品系在电压门控钠通道中具有靶位点突变并上调代谢活动。 Akdr(冈比亚按蚊)和波多黎各(埃及伊蚊)菌株的抗性比率分别为 9.2 和 12.2。总体而言,这项研究表明 DFDT 不太可能成为一种可行的公共卫生病媒控制杀虫剂。
更新日期:2020-11-01
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