Background

Evidence indicates the positive effects of zinc on insulin resistance and oxidative stress in metabolic syndrome or diabetes. Non-alcoholic fatty liver disease (NAFLD) is the main hepatic manifestation of insulin resistance and metabolic syndrome. The present study is the first clinical trial that evaluated the effects of zinc supplementation on metabolic and oxidative stress status in overweight/obese patients with NAFLD undergoing calorie- restriction diet. Methods: Fifty six overweight/obese patients with confirmed mild to moderate NAFLD using ultrasonography were randomly allocated to receive 30 mg elemental zinc supplement (n = 29) or placebo (n = 27) along with weight loss diet for 12 weeks. Serum levels of zinc, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), lipid profile, serum superoxide dismutas1 (SOD1) and malondialdhyde (MDA) levels were assessed.

Results

Serum levels of insulin, SOD1, MDA and HOMA-IR were improved in the treatment group (p < 0.05). Within group comparison showed significant reduction in serum FBS, HbA_1C, TC, LDL-c and TG in the treatment group. Conclusion: Zinc supplementation for three months improved insulin resistance and oxidative stress status in overweight/obese NAFLD patients with no beneficial effects on lipid profiles over weight loss diet. Registration ID in IRCT (IRCT NO: 20181005041238N1).

中文翻译：

---

补锌对患有非酒精性脂肪肝的超重/肥胖患者的代谢特征和氧化应激的影响：一项随机、双盲、安慰剂对照试验。

背景

有证据表明锌对代谢综合征或糖尿病患者的胰岛素抵抗和氧化应激有积极作用。非酒精性脂肪肝（NAFLD）是胰岛素抵抗和代谢综合征的主要肝脏表现。本研究是第一项临床试验，旨在评估补锌对超重/肥胖 NAFLD 患者进行热量限制饮食的代谢和氧化应激状态的影响。方法：56 名超重/肥胖患者通过超声检查确诊为轻度至中度 NAFLD，随机分配接受 30 毫克元素锌补充剂（n = 29）或安慰剂（n = 27）以及减肥饮食，为期 12 周。血清锌水平、评估估计胰岛素抵抗的稳态模型 (HOMA-IR)、脂质谱、

结果

治疗组的胰岛素、SOD1、MDA 和 HOMA-IR 的血清水平有所改善（p < 0.05）。组内比较显示治疗组中血清 FBS、HbA _1C、TC、LDL-c 和 TG显着降低。结论：三个月的锌补充剂可改善超重/肥胖 NAFLD 患者的胰岛素抵抗和氧化应激状态，但与减肥饮食相比，对血脂谱没有有益影响。IRCT 中的注册 ID（IRCT 编号：20181005041238N1）。