The objective of the work was to improve the intestinal stability and pH sensitive release of quercetin in the gastrointestinal tract. To achieve this aim, novel quercetin loaded pH sensitive hydrogel beads of gellan gum were developed through an ionic cross-linking technique using calcium chloride (CaCl₂) as cross-linking agents. Field emission scanning electron microscopy (FESEM) was used to characterize the morphological appearance of the prepared hydrogel beads. Drug-polymer and drug-CaCl₂ interaction were studied by using infrared spectroscopy. The important finding of the study was the formation of stable hydrogel beads at a very low concentration of CaCl₂ (0.3 % w/v). There was a drug polymer interaction in addition to polymer and CaCl₂ interaction that is confirmed by infrared spectroscopy. All the formulation shows good entrapment efficiencies within the range of 58.56–93.71 %. The prepared beads exhibited a pH responsive swelling behavior with maximum swelling at the simulated intestinal fluid (pH 7.4) (SIF). Hydrogel beads also showed a pH responsive release behavior and sustained release of drug at SIF. Moreover, the intestinal stability of quercetin was improved when encapsulated in gellan gum hydrogel beads in comparison to the solution containing quercetin.

这项工作的目的是改善槲皮素在胃肠道中的肠道稳定性和pH敏感释放。为了达到这个目的，通过使用氯化钙（CaCl ₂）作为交联剂的离子交联技术开发了新型的吉兰糖胶中槲皮素负载的pH敏感水凝胶珠。场发射扫描电子显微镜（FESEM）用于表征所制备的水凝胶珠的形态外观。通过红外光谱研究了药物-聚合物和药物-CaCl _2的相互作用。该研究的重要发现是在非常低的CaCl ₂（0.3％w / v）浓度下形成稳定的水凝胶珠。除了聚合物和CaCl ₂以外，还有药物聚合物相互作用红外光谱证实了相互作用。所有配方在58.56–93.71％的范围内均显示出良好的包封率。制备的珠粒表现出pH响应的溶胀行为，在模拟的肠液（pH 7.4）（SIF）处具有最大溶胀。水凝胶珠在SIF时也显示出pH响应释放行为和药物的持续释放。而且，与包含槲皮素的溶液相比，当将其包裹在结冷胶水凝胶珠中时，槲皮素的肠稳定性得到改善。