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Electromagnetic evidence that benign epileptiform transients of sleep are traveling, rotating hippocampal spikes
Clinical Neurophysiology ( IF 3.7 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.clinph.2020.07.023
Richard Wennberg , Apameh Tarazi , Dominik Zumsteg , Luis Garcia Dominguez

OBJECTIVE Benign epileptiform transients of sleep (BETS) have a unique voltage topography and a posteriorly propagating, inferiorly rotating diphasic EEG pattern. The source generators of BETS have not been definitively identified. We aimed to clarify the cerebral localization of BETS using MEG and electromagnetic source imaging (EMSI). METHODS We analyzed BETS recorded with simultaneous MEG and EEG in four patients with epilepsy. Magnetic source imaging (MSI) and EMSI using equivalent current, single moving and rotating dipole inverse models was performed on averaged BETS potentials. MEG beamforming was performed in one case with abundant BETS. RESULTS MSI and EMSI revealed hippocampal dipole source maxima in all cases, with current flow direction rotating from inferomedial to superomedial or superolateral between the first and second BETS peaks. Moving dipole analyses revealed spatiotemporal propagation along the anterior-posterior hippocampal axis and concomitant electromagnetic field rotation. Beamformer source reconstruction revealed an identical hippocampal localization. CONCLUSIONS Converging evidence from different electromagnetic inverse modeling methods indicates that BETS are traveling, rotating hippocampal spikes, whose diphasic waveform is due to back and forth propagation along the anterior-posterior axis of the hippocampus. SIGNIFICANCE The hippocampal localization and longitudinal, rotating propagation pattern of BETS raises the possibility of a sleep-related functional role for these hippocampal spikes.

中文翻译:

电磁证据表明良性癫痫样睡眠瞬变正在传播,海马尖峰旋转

目的 良性癫痫样睡眠瞬态 (BETS) 具有独特的电压分布和向后传播、向下旋转的双相 EEG 模式。BETS 的源生成器尚未确定。我们旨在使用 MEG 和电磁源成像 (EMSI) 阐明 BETS 的大脑定位。方法我们分析了四名癫痫患者同时记录的 MEG 和 EEG 记录的 BETS。使用等效电流、单移动和旋转偶极子逆模型的磁源成像 (MSI) 和 EMSI 在平均 BETS 电位上进行。在一种具有大量 BETS 的情况下执行 MEG 波束成形。结果 MSI 和 EMSI 在所有情况下都显示海马偶极子源极大值,电流方向在第一个和第二个 BETS 峰之间从下内侧旋转到上内侧或上外侧。移动偶极子分析揭示了沿前后海马轴的时空传播和伴随的电磁场旋转。波束成形器源重建显示相同的海马定位。结论 来自不同电磁反演建模方法的汇总证据表明 BETS 是行进的、旋转的海马尖峰,其双相波形是由于沿海马体前后轴的来回传播。意义 BETS 的海马定位和纵向旋转传播模式提高了这些海马尖峰与睡眠相关的功能作用的可能性。波束成形器源重建显示相同的海马定位。结论 来自不同电磁反演建模方法的汇总证据表明 BETS 是行进的、旋转的海马尖峰,其双相波形是由于沿海马体前后轴的来回传播。意义 BETS 的海马定位和纵向旋转传播模式提高了这些海马尖峰与睡眠相关的功能作用的可能性。波束成形器源重建显示相同的海马定位。结论 来自不同电磁反演建模方法的汇总证据表明 BETS 是行进的、旋转的海马尖峰,其双相波形是由于沿海马体前后轴的来回传播。意义 BETS 的海马定位和纵向旋转传播模式提高了这些海马尖峰与睡眠相关的功能作用的可能性。
更新日期:2020-12-01
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