Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nanoparticles, preparing ultrasmall sized (< 6 nm) particles with precisely-defined structures has remained a grand challenge. In this work, we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes (POSS)-based polyphenol nanoparticles (T₈-, T₁₀-, and T₁₂-GAPOSS) by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael “click” reactions. Those polyphenol nanoparticles exhibited strong free radical scavenging capacity, good biocompatibility and ability to resist cell oxidative damage, which demonstrated great potentials in inhibiting oxidative stress induced pathologies.

尽管已经为天然多酚官能化的纳米颗粒的结构和功能定制做出了巨大努力，但是制备具有精确定义的结构的超小尺寸（<6 nm）颗粒仍然是一项艰巨的挑战。在这项工作中，我们报告了通过使用植物多酚没食子将POSS表面精确功能化，制备超小且结构精确的多面体低聚倍半硅氧烷（POSS）基多酚纳米颗粒（T _8-，T _10-和T ₁₂ -GAPOSS）。通过酸单位硫醇-迈克尔“点击”反应。这些多酚纳米颗粒具有很强的清除自由基能力，良好的生物相容性和抵抗细胞氧化损伤的能力，在抑制氧化应激诱导的病理学方面具有巨大潜力。