Nanoclay-based drug delivery vehicle has acquired immense recognition owing to its unique physico-chemical properties. In this study, tetracycline hydrochloride (TCH) drug was intercalated into the interlayer gallery of montmorillonite (Mt) clay by a cation exchange process. The intercalated nanocomposites were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive X-ray and thermogravimetric study. It was evident from the characterization that TCH drug was successfully intercalated into the interlayer gallery of Mt clay. These clay-based formulations exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria on analyses via zone inhibition methods. An in-vitro drug release study was performed in phosphate buffer at physiological temperature and interestingly it exhibited sustained and controlled release of TCH from the nanocomposites, after an initial burst-out effect. Overall, this study showed that these nanocomposite materials have immense potential for use in controlled drug delivery strategies for antibacterial treatment.

中文翻译：

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用于持续递送盐酸四环素的抗菌纳米粘土基生物材料

基于纳米粘土的药物递送载体由于其独特的物理化学性质而获得了广泛的认可。在这项研究中，四环素盐酸盐 (TCH) 药物通过阳离子交换过程插入蒙脱石 (Mt) 粘土的层间通道。通过傅里叶变换红外光谱、X 射线衍射、能量色散 X 射线和热重研究对插层纳米复合材料进行了表征。从表征中可以明显看出，TCH药物成功地嵌入到Mt粘土的夹层通道中。通过区域抑制方法的分析，这些粘土基配方对革兰氏阳性菌和革兰氏阴性菌均表现出抗菌活性。在生理温度下在磷酸盐缓冲液中进行了体外药物释放研究，有趣的是，在最初的爆发效应后，它表现出从纳米复合材料中持续和控制释放 TCH。总的来说，这项研究表明，这些纳米复合材料在用于抗菌治疗的受控药物递送策略中具有巨大的潜力。