Bone marrow-derived mesenchymal stem cells (BMSCs) play a critical role in the osseointegration of bone and orthopedic implant. However, osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium's inherent defects. Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate. Here, we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys. We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration, and discuss recent advances in understanding their role in regenerative medicine. We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

中文翻译：

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在整形外科植入物表面促进骨髓间充质干细胞成骨的方法。

骨髓间充质干细胞（BMSC）在骨骼和整形外科植入物的骨整合中起关键作用。然而，由于钛固有的缺陷，必须改善钛基植入物与周围骨组织之间的骨整合。表面修饰是一种通用的技术，可用于创建具有指导意义的生物材料，从而主动指导干细胞的命运。在这里，我们总结了目前在钛及其合金表面上促进BMSC成骨的方法。我们将重点介绍利用钛及其合金的独特特性来促进组织再生，并讨论了解钛在再生医学中的作用的最新进展。我们旨在为骨科植入物表面促进BMSC成骨的方法提供系统且全面的综述。