Mesenchymal stem cells (MSCs) have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative properties. Recently, mounting studies have implicated the therapeutic potency of MSCs mostly due to the bioactive factors they produce. Extracellular vesicles (EVs) derived from MSCs have been identified as a promising cell-free therapy due to low immunogenicity. Rheumatic disease, primarily including rheumatoid arthritis and osteoarthritis, is a group of diseases in which immune dysregulation and chronic progressive inflammation lead to irreversible joint damage. Targeting MSCs and MSC-derived EVs may be a more effective and promising therapeutic strategy for rheumatic diseases.

中文翻译：

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间充质干细胞和间充质干细胞来源的细胞外囊泡：在风湿性疾病中的潜在作用。

间充质干细胞（MSCs）由于具有免疫调节和再生特性，已在风湿性疾病中得到广泛研究。最近，越来越多的研究表明，MSC的治疗效力主要是由于它们产生的生物活性因子。源自MSC的细胞外囊泡（EVs）由于免疫原性低而被鉴定为一种有前途的无细胞疗法。风湿性疾病，主要包括类风湿性关节炎和骨关节炎，是其中免疫失调和慢性进行性炎症导致不可逆的关节损伤的一组疾病。针对MSC和MSC衍生的EV可能是风湿性疾病更有效和有希望的治疗策略。