A removable directing group-assisted Rh(III)-catalyzed direct C–H bond activation/annulation cascade to synthesize highly fused isoquinolines,Organic Chemistry Frontiers

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A removable directing group-assisted Rh(III)-catalyzed direct C–H bond activation/annulation cascade to synthesize highly fused isoquinolines
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-08-27 , DOI: 10.1039/d0qo00786b
Yilang Cheng _{1,

2,

3,

4,

5} , Xu Han _{1,

2,

3,

4,

5} , Junyou Li _{1,

2,

3,

4,

5} , Yu Zhou _{1,

2,

3,

4,

5} , Hong Liu _{1,

2,

3,

4,

5}

Affiliation

An azomethine imine-directed Rh(III)-catalyzed C–H functionalization/annulation cascade to construct highly fused isoquinoline scaffolds, in which the azomethine imine was used as a removable directing group and could be removed in situ under mild reaction conditions with good to excellent yields, accompanied by a broad substrate scope and good functional group tolerance was developed. Notably, this strategy could be further extended to late-stage modification of drug molecules, offering more potential in drug discoveries.

中文翻译：

可移动的导向基团辅助的Rh（III）催化的直接C–H键活化/环化级联反应，以合成高度稠合的异喹啉

甲亚胺亚胺定向的Rh（III）催化的C–H功能化/环构级联反应，以构建高度融合的异喹啉支架，其中将甲亚胺亚胺用作可移动的导向基团，可以在温和的反应条件下原位去除，具有良好的开发出了优异的产率，并伴随着广泛的底物范围和良好的官能团耐受性。值得注意的是，该策略可以进一步扩展到药物分子的后期修饰，在药物发现中提供更大的潜力。

更新日期：2020-10-13

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