Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that serves as a key regulator of cellular physiology in the context of apoptosis, mitosis, and DNA damage responses. Canonically, PP2A functions as a tumor suppressor gene. However, recent evidence suggests that inhibiting PP2A activity in tumor cells may represent a viable approach to enhancing tumor sensitivity to chemoradiotherapy as such inhibition can cause cells to enter a disordered mitotic state that renders them more susceptible to cell death. Indeed, there is evidence that inhibiting PP2A can slow tumor growth following radiotherapy in a range of cancer types including ovarian cancer, liver cancer, malignant glioma, pancreatic cancer, and nasopharyngeal carcinoma. In the present review, we discuss current understanding of the role of PP2A in tumor radiotherapy and the potential mechanisms whereby it may influence this process.

中文翻译：

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PP2A与肿瘤放疗


蛋白磷酸酶 2A (PP2A) 是一种丝氨酸/苏氨酸磷酸酶，在细胞凋亡、有丝分裂和 DNA 损伤反应中充当细胞生理学的关键调节剂。通常，PP2A 充当肿瘤抑制基因。然而，最近的证据表明，抑制肿瘤细胞中的 PP2A 活性可能是增强肿瘤对放化疗敏感性的可行方法，因为这种抑制会导致细胞进入无序的有丝分裂状态，使它们更容易发生细胞死亡。事实上，有证据表明，抑制 PP2A 可以减缓多种癌症类型放疗后的肿瘤生长，包括卵巢癌、肝癌、恶性神经胶质瘤、胰腺癌和鼻咽癌。在本综述中，我们讨论了目前对 PP2A 在肿瘤放疗中的作用的理解以及它可能影响这一过程的潜在机制。