Replacement strategies for non-green dipolar aprotic solvents,Green Chemistry

当前位置： X-MOL 学术 › Green Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Replacement strategies for non-green dipolar aprotic solvents
Green Chemistry ( IF 9.3 ) Pub Date : 2020-08-27 , DOI: 10.1039/d0gc02149k
Feng Gao _{1,

2,

3,

4,

5} , Rongxian Bai _{1,

2,

3,

4,

5} , Francesco Ferlin _{6,

7,

8,

9,

10} , Luigi Vaccaro _{6,

7,

8,

9,

10} , Minghao Li _{1,

2,

3,

4,

5} , Yanlong Gu _{1,

2,

3,

4,

5}

Affiliation

Dipolar aprotic solvents (DMSO, DMF, DMAc, NMP, etc.) have been widely used in organic synthesis and pharmaceutical research because of their remarkable polarities and solubilities, while most of them are not green because of their detrimental effects on human health and hazards to the natural environment caused by their inescapable toxicity as well as large wastewater streams and high-energy-input requirements. This dangerous situation is further complicated by the surging demand of dipolar aprotic solvents in the research and development in the pharmaceutical industry and other chemical processes. Therefore, minimizing and avoiding the use of such solvents has become one of the most important facets of green chemistry. So far, substantial efforts have been devoted in response to this problem that has entailed the development of green and novel reaction systems that fulfill numerous requirements, which are also met by traditional dipolar aprotic solvents. In this context, this review summarizes the methods and strategies for replacing non-green polar aprotic solvents, which mainly include direct replacement with new green alternatives and utilization of polarized catalysts in common green solvents for avoiding the use of conventional polar aprotic solvents. Besides, the strengths and weaknesses of these two strategies are analyzed. Compared with the direct replacement strategy, the rational design of polarized catalysts not only expands the choice of green solvents, but also provides new possibilities for the design and preparation of multifunctional catalysts, suggesting a promising prospect in substitution strategies for non-green polar aprotic solvents. Certainly, other methods are being explored to realize the green and sustainable replacement of conventional dipolar aprotic solvents in an economical and handy tactic.

中文翻译：

非绿色偶极非质子溶剂的替代策略

偶极非质子溶剂（DMSO，DMF，DMAc，NMP等。）由于其极好的极性和溶解性而被广泛用于有机合成和药物研究中，而大多数由于其不可避免的毒性以及对人体健康的有害影响以及对自然环境的危害而并非绿色。废水流和高能量输入要求。在制药工业和其他化学过程的研究与开发中，偶极非质子溶剂的需求激增使这种危险情况更加复杂。因此，最小化和避免使用此类溶剂已成为绿色化学最重要的方面之一。到目前为止，为解决这个问题已付出了巨大的努力，这需要开发出满足众多要求的绿色新颖的反应系统，传统的偶极非质子溶剂也可以满足这些要求。在此背景下，本综述总结了替代非绿色极性非质子溶剂的方法和策略，主要包括用新的绿色替代品直接替代以及在常规绿色溶剂中利用极化催化剂以避免使用常规极性非质子溶剂。此外，分析了这两种策略的优缺点。与直接替代策略相比，极化催化剂的合理设计不仅扩大了绿色溶剂的选择范围，而且为多功能催化剂的设计和制备提供了新的可能性，这为非绿色极性非质子溶剂的替代策略提供了广阔的前景。。当然，

更新日期：2020-10-05

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11