Green Approach for Visible-Light-Induced Direct Functionalization of 2-Methylquinolines.,The Journal of Organic Chemistry

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Green Approach for Visible-Light-Induced Direct Functionalization of 2-Methylquinolines.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-08-27 , DOI: 10.1021/acs.joc.0c01203
Juliana A Dantas ₁ , Radell Echemendía ₁ , Marilia S Santos ₁ , Márcio W Paixão ₁ , Marco Antonio B Ferreira ₁ , Arlene G Corrêa ₁

Affiliation

A transition metal- and oxidant-free visible light-photoinduced protocol for direct functionalization of 2-methylquinolines has been developed. This protocol enabled the C–H functionalization of substituted 2-methylquinolines with diacetyl or ethyl pyruvate, under environmentally friendly conditions. A mechanistic investigation based on density functional theory (DFT) calculations provided details about the origins of reactivity and selectivity.

中文翻译：

可见光诱导的2-甲基喹啉直接功能化的绿色方法。

已经开发了无过渡金属和无氧化剂的可见光光诱导方案，用于2-甲基喹啉的直接功能化。该协议可以在环境友好的条件下用二乙酰基或丙酮酸乙酯对取代的2-甲基喹啉进行C–H官能化。基于密度泛函理论（DFT）计算的机械研究提供了有关反应性和选择性起源的详细信息。

更新日期：2020-09-20

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