In this work, the solid–liquid equilibrium of 4-(bromomethyl)-2(1H)-quinolinone in methanol, ethanol, n-propanol, isopropanol, n-butanol, acetonitrile, 1,4-dioxane, toluene, 2-butanone, dimethylformamide (DMF), n-methyl pyrrolidone (NMP), and dimethyl sulfoxide (DMSO) within the temperature range from 273.15 to 313.15 K was studied. The solubility of 4-(bromomethyl)-2(1H)-quinolinone was the highest in DMSO and the lowest in toluene at all studied temperatures. As expected, the solubility of 4-(bromomethyl)-2(1H)-quinolinone increased with an increase in temperature in the 12 tested solvents. At 313.15 K, the mole solubility of 4-(bromomethyl)-2(1H)-quinolinone was ranked in the following order: DMSO (3.81 × 10^–2) > NMP (1.426 × 10^–2) > DMF (8.28 × 10^–3) > 1,4-dioxane (1.37 × 10^–3) > 2-butanone (7.92 × 10^–4) > n-butanol (5.58 × 10^–4) > n-propanol (4.76 × 10^–4) > ethanol (3.85 × 10^–4) > isopropanol (3.60 × 10^–4) > methanol (3.03 × 10^–4) > acetonitrile (2.23 × 10^–4) > toluene (0.56 × 10^–4). The acquired solubility data of 4-(bromomethyl)-2(1H)-quinolinone in the studied solvents were correlated using the modified Apelblat equation and the λh equation. The maximum value of the relative average deviation (RAD) was 3.44%, and all values of RAD in the modified Apelblat equation were smaller than those in the λh equation; therefore, the modified Apelblat equation is more suitable to correlate the results. The obtained solubility and thermodynamic studies would be very helpful for optimizing the purification process of 4-(bromomethyl)-2(1H)-quinolinone.

中文翻译：

---

在273.15至313.15 K的温度范围内，4-（溴甲基）-2（1H）-喹啉酮在不同纯溶剂中的溶解度测定和相关性

在这项工作中，4-（溴甲基）-2（1H）-喹啉酮在甲醇，乙醇，正丙醇，异丙醇，正丁醇，乙腈，1,4-二恶烷，甲苯，2-丁酮中的固液平衡研究了温度范围为273.15至313.15 K的二甲基甲酰胺（DMF），正甲基吡咯烷酮（NMP）和二甲基亚砜（DMSO）。在所有研究温度下，4-（溴甲基）-2（1H）-喹啉酮在DMSO中的溶解度最高，在甲苯中的溶解度最低。如预期的那样，在12种测试溶剂中，4-（溴甲基）-2（1H）-喹啉酮的溶解度随温度的升高而增加。在313.15 K，按以下顺序排列4-（溴甲基）-2（1H）-喹啉酮的摩尔溶解度：DMSO（3.81×10 ^–2）> NMP（1.426×10^-2）> DMF（8.28×10 ^-3）> 1,4-二恶烷（1.37×10 ^-3）> 2-丁酮（7.92×10 ^-4）> Ñ丁醇（5.58×10 ^-4）> ñ -丙醇（4.76×10 ^–4）>乙醇（3.85×10 ^–4）>异丙醇（3.60×10 ^–4）>甲醇（3.03×10 ^–4）>乙腈（2.23×10 ^–4）>甲苯（0.56×10 ^–4）。的4-获取的溶解度数据（溴甲基）-2（1H） -喹啉酮在所研究的溶剂中使用改性Apelblat方程和λ是相关ħ方程。相对平均偏差的最大值（RAD）为3.44％，和改性Apelblat方程中RAD的所有值均高于λ较小ħ方程; 因此，修改后的Apelblat方程更适合于关联结果。获得的溶解度和热力学研究将对优化4-（溴甲基）-2（1H）-喹啉酮的纯化工艺非常有帮助。