Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H₂S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H₂S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H₂S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.

中文翻译：

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硫化氢通过影响 NLRP3 炎性体发挥重要作用

炎症小体是由多种蛋白质组成的复合物，是天然免疫系统的重要组成部分。核苷酸结合寡聚化域样受体蛋白 3 (NLRP3) 炎症小体由 NLRP3、凋亡相关斑点样蛋白 (ASC) 和 pro-caspase-1 组成。它在许多疾病中起着重要作用。硫化氢 (H ₂ S) 是调节许多生理和病理过程的重要信号分子。最近的研究表明H ₂ S通过影响NLRP3炎性体在多种疾病中发挥抗炎和促炎作用，但其机制尚不完全清楚。本文综述了 H ₂影响的进展S对NLRP3炎症小体及其作用机制的研究为近年来的深入研究提供了理论依据。