Direct cell reprogramming, also called transdifferentiation, has great potential for tissue engineering and regenerative medicine. Boolean networks, a popular modelling framework for gene regulatory networks, make it possible to identify intervention targets for direct cell reprogramming with computational methods. In this work, we present our software, CABEAN, for the control of asynchronous Boolean networks. CABEAN identifies efficacious nodes, whose perturbations can drive the dynamics of a network from a source attractor (the initial cell type) to a target attractor (the desired cell type). CABEAN provides several control methods integrating practical constraints. Thus, it has the ability to provide a rich set of control sets, such that biologists can select suitable ones for validation based on specific experimental settings.

中文翻译：

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CABEAN：一种用于控制异步布尔网络的软件。

直接细胞重编程，也称为转分化，在组织工程和再生医学中具有巨大潜力。布尔网络是一种用于基因调控网络的流行建模框架，它使得可以使用计算方法来确定用于直接细胞重编程的干预目标。在这项工作中，我们介绍了用于异步布尔网络控制的软件CABEAN。CABEAN识别有效的节点，这些节点的干扰可以驱动网络从源吸引子（初始细胞类型）到目标吸引子（所需细胞类型）的动力学。CABEAN提供了多种结合实际约束的控制方法。因此，它具有提供丰富的控制集的能力，因此生物学家可以根据特定的实验设置选择合适的控制集进行验证。