SummaryClinical outcomes following frozen–thawed cleavage embryo transfer versus frozen–thawed blastocyst transfer in high responder patients undergoingin vitrofertilisation/intracytoplasmic sperm injection cycles are still debated. In a retrospective study, 106 high responder patients who were candidate for ‘freeze-all embryos’ were recruited. Frozen–thawed embryos were transferred at the cleavage stage (n= 53) or the blastocyst stage (n= 53). Clinical pregnancy was considered as the primary outcome and chemical pregnancy, ongoing pregnancy, implantation rate, and fertilization rate, as well as miscarriage rate, were measured as the secondary outcome. Clinical (47.2% vs. 24.5%), chemical (56.6% vs. 32.1%), and ongoing pregnancy rates (37.7% vs. 17%) as well as implantation rates (33.6% vs. 13.5%) were significantly higher in the blastocyst group compared with the cleavage group respectively (P< 0.05). Miscarriage rate was comparable between groups (P> 0.05). Transfer of frozen–thawed embryos at the blastocyst stage was preferable in the high responder patients to increase implantation, pregnancy and live birth rates compared with cleavage stage embryo transfer.

中文翻译：

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高反应患者的冻融卵裂期与囊胚期胚胎移植

摘要冻融卵裂胚胎移植与冻融囊胚移植在高反应率患者中的临床结果体外受精/胞浆内精子注射周期仍有争议。在一项回顾性研究中，招募了 106 名“冷冻所有胚胎”候选的高反应患者。在卵裂期移植冻融胚胎（n= 53) 或囊胚期 (n= 53)。临床妊娠被认为是主要结果，化学妊娠、持续妊娠、着床率和受精率以及流产率被测量为次要结果。临床（47.2% 对 24.5%）、化学（56.6% 对 32.1%）和持续妊娠率（37.7% 对 17%）以及植入率（33.6% 对 13.5%）在囊胚组与卵裂组分别比较（磷< 0.05)。组间流产率具有可比性（磷> 0.05)。与卵裂期胚胎移植相比，高反应患者优选在囊胚期移植冻融胚胎，以提高着床率、妊娠率和活产率。