Social contact is one of the best methods for reducing stigma, and the effect may be associated with emotional response and social cognition. The amygdala is a key region of these functions and can be divided into three subregions, each of which has a different function and connectivity. We investigated whether the amygdala subregion-related functional connectivity is associated with the effect of anti-stigma interventions on reducing mental health-related stigma in a randomized controlled trial (RCT) over 12 months. Healthy young adults [n = 77, age, mean (SD) = 21.23 (0.94) years; male, n = 48], who were subsampled from an RCT (n = 259) investigating the effect of anti-stigma interventions, using filmed social contacts (FSC) or internet self-learning (INS), on reducing stigma, underwent 10 min resting-state functional magnetic resonance imaging between the trial registration and 12 months follow-up. The extent of stigma was assessed at the baseline, post-intervention and 12 month follow-up surveys, using the Japanese-language version of the Social Distance Scale (SDSJ), to assess negative emotional attitude toward people with schizophrenia. We compared associations between amygdala subregion-related functional connectivity and changes in the SDSJ scores for 12 months across the control, INS, and FSC groups. Associations between the change in stigma for 12 months and the superficial (SF) subregion of the amygdala-related connectivity in the intracalcarine cortex [(x, y, z) = (−8, −66, 12), z = 4.21, PFWE–corrected = 0.0003, cluster size = 192] differed across groups. The post hoc analysis showed that the SF–intracalcarine cortex connectivity was negatively correlated with the change in stigma only in the FSC group. The current results indicate that greater SF–intracalcarine cortex connectivity is associated with a better response to the FSC interventions, suggesting that biological variability could underlie the long-term effect of anti-stigma interventions on stigma in the real world.

中文翻译：

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社交接触后 12 个月杏仁核亚区相关功能连接与耻辱减少之间的关联：一项随机对照试验亚组的功能性神经影像学研究

社会接触是减少污名的最佳方法之一，其效果可能与情绪反应和社会认知有关。杏仁核是这些功能的关键区域，可分为三个子区域，每个子区域都具有不同的功能和连通性。我们在一项为期 12 个月的随机对照试验 (RCT) 中调查了杏仁核亚区相关的功能连接是否与反污名干预对减少心理健康相关污名的影响有关。健康的年轻人 [n = 77，年龄，平均 (SD) = 21.23 (0.94) 岁；男性，n = 48]，他们是从 RCT (n = 259) 中抽取的子样本，该研究使用拍摄的社交接触 (FSC) 或互联网自学 (INS) 来调查反污名干预对减少污名的影响，在试验注册和 12 个月的随访之间进行了 10 分钟的静息状态功能磁共振成像。在基线、干预后和 12 个月的随访调查中，使用日语版的社会距离量表 (SDSJ) 评估耻辱程度，以评估对精神分裂症患者的负面情绪态度。我们比较了对照组、INS 和 FSC 组 12 个月内杏仁核亚区相关功能连接与 SDSJ 评分变化之间的关联。12 个月的柱头变化与距内皮层杏仁核相关连接的浅表 (SF) 子区域之间的关联 [(x, y, z) = (-8, -66, 12), z = 4.21, PFWE –更正 = 0.0003，簇大小 = 192] 各组不同。事后分析表明，仅在 FSC 组中，SF-钙质内皮层连接与柱头变化呈负相关。目前的结果表明，更大的 SF-钙质内皮层连接与对 FSC 干预的更好反应相关，这表明生物变异性可能是反污名干预对现实世界中污名的长期影响的基础。