Background: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the diagnostic tool of choice for pancreatic solid mass lesions. Pancreatic lymphomas represent an infrequent and challenging cytologic diagnosis. Our aim was to determine the diagnostic value of cellblock (CB) in the diagnosis of pancreatic lymphomas. Methods: We retrieved pancreatic EUS-FNAs performed over 10-years from our institution’s database. We correlated the cytologic and CB diagnosis with the histologic diagnosis as a gold standard. Results: We found 5 cases (2 women and 3 men; age range, 37–66 years [average age, 52 years]) of pancreatic lymphomas with histologic follow-up biopsies. They included 1 case of T-cell lymphoma (TCL), 1 case of plasma cell neoplasm (multiple myeloma [MM]), 1 case of diffuse large B-cell lymphoma (DLBCL), 1 case of classic Hodgkin lymphoma (HL), and 1 case of high-grade B-cell lymphoma (HGBCL). Cytologically, the cases of HL and DLBCL were suspected, the cases of TCL and MM were confused with undifferentiated carcinoma and neuroendocrine carcinoma, and the case of HGBCL was inconclusive. CB samples were of value in highlighting the morphologic details of lymphomas and allowed confirmation, proper classification, and grading of the lymphomas using immunohistochemistry that matched tissue biopsies. Conclusions: EUS-FNA smears with CBs are helpful diagnostic tools, differentiating lymphomas from other malignancies and from nonneoplastic lymphocyte-rich lesions. CBs allow proper classification and grading of cases of pancreatic lymphomas.
Acta Cytologica

中文翻译：

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细胞阻断剂在胰腺淋巴瘤诊断中的价值。

背景：内镜超声引导下细针穿刺术（EUS-FNA）是胰腺实体瘤病变的首选诊断工具。胰腺淋巴瘤是一种罕见且具有挑战性的细胞学诊断。我们的目的是确定细胞阻断剂（CB）在胰腺淋巴瘤诊断中的诊断价值。方法：我们从我们机构的数据库中检索了超过10年的胰腺EUS-FNA。我们将细胞学和CB诊断与组织学诊断相关联作为金标准。结果：我们发现了5例胰腺淋巴瘤（2例女性和3例男性；年龄范围37-66岁[平均年龄52岁]），并进行了组织学随访活检。其中包括1例T细胞淋巴瘤（TCL），1例浆细胞瘤（多发性骨髓瘤[MM]），1例弥漫性大B细胞淋巴瘤（DLBCL），1例经典霍奇金淋巴瘤（HL）， 1例高度B细胞淋巴瘤（HGBCL）。细胞学上怀疑是HL和DLBCL，TCL和MM是未分化癌和神经内分泌癌的混淆，HGBCL是不确定的。CB样品对于突出淋巴瘤的形态学细节具有重要价值，并可以使用与组织活检相匹配的免疫组织化学技术对淋巴瘤进行确认，正确分类和分级。结论：EUS-FNA CB涂片检查是有用的诊断工具，可将淋巴瘤与其他恶性肿瘤以及富含非肿瘤性淋巴细胞的病变区分开。CB可以对胰腺淋巴瘤病例进行适当的分类和分级。
细胞学学报