Abstract Self-assembled hydrogels from 9-fluorenylmethoxycarbonyl-modified diphenylalanine (Fmoc-FF) peptides were evaluated as potential vehicles for drug delivery. During self-assembly of Fmoc-FF, high concentrations of indomethacin (IDM) drugs were shown to be incorporated into the hydrogels. The β-sheet arrangement of peptides was found to be predominant in Fmoc-FF–IDM hydrogels regardless of the IDM content. The release mechanism for IDM displayed a biphasic profile comprising an initial hydrogel erosion-dominated stage followed by the diffusion-controlled stage. Small amounts of polyamidoamine dendrimer (PAMAM) added to the hydrogel (Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%) resulted in a more prolonged IDM release compared with Fmoc-FF 0.5%–IDM 0.5% hydrogel. Furthermore, these IDM-loaded hydrogels demonstrated excellent thixotropic response and injectability, which make them suitable candidates for use as injectable self-healing matrices for drug delivery. Graphical abstract High concentrations of IDM drugs can be incorporated into hydrogels during the self-assembly of Fmoc-FF. Small amounts of PAMAM added to the hydrogel (Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%) resulted in more prolonged IDM release when compared with Fmoc-FF 0.5%–IDM 0.5% hydrogel.

中文翻译：

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Fmoc-二苯丙氨酸基水凝胶作为药物递送的潜在载体

摘要 9-芴基甲氧基羰基修饰的二苯丙氨酸 (Fmoc-FF) 肽自组装水凝胶被评估为潜在的药物递送载体。在 Fmoc-FF 的自组装过程中，高浓度的吲哚美辛 (IDM) 药物被纳入水凝胶中。无论 IDM 含量如何，发现肽的 β 折叠排列在 Fmoc-FF-IDM 水凝胶中占主导地位。IDM 的释放机制显示出双相曲线，包括初始水凝胶侵蚀主导阶段，然后是扩散控制阶段。与 Fmoc-FF 0.5%–IDM 0.5% 水凝胶相比，添加到水凝胶（Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%）中的少量聚酰胺胺树枝状聚合物（PAMAM）导致 IDM 释放时间更长。此外，这些载有 IDM 的水凝胶表现出优异的触变性和可注射性，这使它们成为用作药物递送的可注射自修复基质的合适候选者。图形摘要 在 Fmoc-FF 的自组装过程中，可以将高浓度的 IDM 药物掺入水凝胶中。与 Fmoc-FF 0.5%–IDM 0.5% 水凝胶相比，向水凝胶中添加少量 PAMAM（Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%）可延长 IDM 释放时间。