A vicious cycle, linking obesity with chronic inflammation, fuels the development and exacerbation of metabolic syndrome and other disorders. Modulation of mitochondrial energy metabolism via interleukin-1β signaling establishes a runaway positive-feedback loop that brings about and reinforces the sequelae of a high-fat diet.

中文翻译：

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在肥胖中，炎症会阻止线粒体的代谢。

肥胖与慢性炎症相关的恶性循环加剧了代谢综合征和其他疾病的发展和恶化。通过白介素-1β信号传导对线粒体能量代谢的调节建立了失控的正反馈回路，该回路引起并增强了高脂饮食的后遗症。