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Can biofeedback-based training alleviate fatigue and vigilance performance in fatigued MS patients?
Neuropsychological Rehabilitation ( IF 1.7 ) Pub Date : 2020-08-27 , DOI: 10.1080/09602011.2020.1808023
Carina Sander 1, 2 , Niclas Braun 3 , Fenja Modes 1 , Hans-Peter Schlake 2 , Paul Eling 4 , Helmut Hildebrandt 1, 5
Affiliation  

ABSTRACT

MS related fatigue might be related to autonomous nervous system (ANS) dysfunctions or to inflammation related vagal (hyper-) activation. Consequently, influencing ANS status may lead to relieve of fatigue. We used two opposite biofeedback interventions to either increase sympathetic (“self-alert training”, SAT) or parasympathetic activation (“progressive muscle relaxation”, PMR). We recorded fatigue status of patients before and after a challenging vigilance task, their behavioural performance on this task, their skin conductance response (SCR), and parameters indicating parasympathetic activity concerning heart rate variability (HRV). We repeated these recordings after the biofeedback training sessions. Patients of the SAT group were able to learn to increase their SCR voluntarily. Patients of the PMR group showed increasing parameters indicating parasympathetic modulation of the HRV. The vigilance task increased their feeling of fatigue. However, there was no effect of biofeedback training on either fatigue status or performance on the vigilance task. Our results show that MS patients can learn to change voluntarily their ANS activity using biofeedback instructions based on SCR and this can be used in future studies to test the postulated link between ANS and fatigue. However, in this experimental intervention we were unable to document a relation between ANS activity and fatigue.

Trial registration: ClinicalTrials.gov identifier: NCT03268187.



中文翻译:

基于生物反馈的训练能否缓解疲劳的 MS 患者的疲劳和警惕性?

摘要

MS 相关疲劳可能与自主神经系统 (ANS) 功能障碍或炎症相关迷走神经(超)激活有关。因此,影响 ANS 状态可能会导致疲劳的缓解。我们使用了两种相反的生物反馈干预来增加交感神经(“自我警觉训练”,SAT)或副交感神经激活(“渐进式肌肉放松”,PMR)。我们记录了患者在执行具有挑战性的警戒任务之前和之后的疲劳状态、他们在该任务中的行为表现、他们的皮肤电导反应 (SCR) 以及指示与心率变异性 (HRV) 相关的副交感神经活动的参数。我们在生物反馈培训课程后重复了这些录音。SAT 组的患者能够学会自愿增加他们的 SCR。PMR 组的患者表现出增加的参数,表明 HRV 的副交感神经调制。警戒任务增加了他们的疲劳感。然而,生物反馈训练对疲劳状态或警戒任务的表现没有影响。我们的结果表明,MS 患者可以学习使用基于 SCR 的生物反馈指令自愿改变他们的 ANS 活动,这可以用于未来的研究,以测试 ANS 与疲劳之间的假设联系。然而,在这个实验干预中,我们无法记录 ANS 活动与疲劳之间的关系。我们的结果表明,MS 患者可以学习使用基于 SCR 的生物反馈指令自愿改变他们的 ANS 活动,这可以用于未来的研究,以测试 ANS 与疲劳之间的假设联系。然而,在这个实验干预中,我们无法记录 ANS 活动与疲劳之间的关系。我们的结果表明,MS 患者可以学习使用基于 SCR 的生物反馈指令自愿改变他们的 ANS 活动,这可以用于未来的研究,以测试 ANS 与疲劳之间的假设联系。然而,在这个实验干预中,我们无法记录 ANS 活动与疲劳之间的关系。

试用注册: ClinicalTrials.gov 标识符:NCT03268187.

更新日期:2020-08-27
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