Abstract

One new meroterpenoid, antroquinonol Y (1), a new ergostane-type sterol, antcamphin Y (2), and a new ergostane-type triterpenoid, antcamphin Z (3), together with 10 known ones (4–13), were isolated from the dish-cultured fungus Antrodia camphorata. Their structures were characterized by extensive NMR and HRESIMS data analyses. The absolute configurations were elucidated by experimental and calculated electronic circular dichroism (ECD) spectral analyses and chemical semi-synthesis. Compounds 1, 3, and 5 exhibited potent inhibitory activities against four human cancer cell lines (U251, HL60, SW480, and A549 cells) with IC₅₀ values of 4.6 to 11.7 μM.

摘要

分离出一种新的类萜类化合物蒽醌醇Y ( 1 )、一种新的麦角甾醇类蚁苦苷 Y ( 2 ) 和一种新的麦角甾醇型三萜类化合物 antcamphin Z ( 3 ) 以及 10 种已知的化合物( 4–13 )来自培养的真菌牛樟芝。它们的结构通过广泛的 NMR 和 HRESIMS 数据分析来表征。通过实验和计算的电子圆二色性 (ECD) 光谱分析和化学半合成阐明了绝对构型。化合物1，3和5表现出有效的抑制活性对四种人类肿瘤细胞系（U251，HL60，SW480，和A549细胞）与IC4.6 到 11.7 μM 的_{50 个}值。