Abstract

Two new milbemycin metabolites, 13α-hydroxymilbemycin β₁₃ (1) and 26-methyl-13α-hydroxymilbemycin β₁₃ (2), were isolated from the fermentation broth of a genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were determined by the comprehensive spectroscopic data, including 1 D, 2 D NMR, MS spectral analysis and the comparison with data from the literature. Compounds 1 and 2 not only exhibited potent acaricidal activities against Tetranychus cinnabarinus, but also had nematocidal activity against Bursaphelenchus xylophilus.

中文翻译：

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来自基因工程菌株 Streptomyces avermitilis AVE-H39 的两种新的 13-羟基化米尔倍霉素代谢物

摘要

从基因工程菌株Streptomyces avermitilis AVE-H39的发酵液中分离出两种新的米尔倍霉素代谢物，13 α-羟基米尔倍霉素β ₁₃ ( 1 ) 和 26-甲基-13 α -羟基米尔倍霉素β ₁₃ ( 2 ) 。它们的结构是通过综合光谱数据确定的，包括一维、二维核磁共振、质谱分析和与文献数据的比较。化合物1和2不仅对朱砂叶螨表现出强效杀螨活性，而且对线虫也有杀线虫活性。松材线虫。