The objective of the current study was to investigate the anti-epileptogenic and anticonvulsant effects of Dorema ammoniacum gum, which is used in Iranian traditional medicine for the treatment of seizures. Animals received pentylenetetrazol (IP, 30 mg/kg/48 h) for inducing seizures. Five different seizure stages were evaluated for 20 min and parameters including maximum seizure stage, the latency to the onset of stage 4, stage 4 duration, and seizure duration were measured. D. ammoniacum (50 and 100 mg/kg) or its vehicle was administered 30 min before or after pentylenetetrazol injection in different groups. In addition, the effective dose of D. ammoniacum (100 mg/kg) on different seizure stages was compared with the common antiseizure drug phenobarbital. In another set of experiments, we investigated the effective dose of D. ammoniacum on fully kindled animals in which an interictal electroencephalogram was recorded by superficial electrodes placed on the skull. The results showed that D. ammoniacum administration, before and after pentylenetetrazol injections, significantly decreased seizure stage, seizure duration, stage 4 duration, and 1/stage 4 latency. The anti-epileptogenic effect of D. ammoniacum was about 50 to 60% of phenobarbital. In addition, D. ammoniacum significantly decreased seizure stage, seizure duration, stage 4 duration, and 1/stage 4 latency when administered to fully kindled animals but had no effect on the power of EEG sub-bands. These results indicate that D. ammoniacum has anti-epileptogenic and anticonvulsant effects in a chemical kindling model of seizures.

中文翻译：

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多瑞玛对大鼠云台诱发癫痫发作及癫痫样脑活动的改善作用

当前研究的目的是研究 Dorema 氨树胶的抗癫痫和抗惊厥作用，Dorema 氨树胶在伊朗传统医学中用于治疗癫痫发作。动物接受戊四唑 (IP, 30 mg/kg/48 h) 以诱导癫痫发作。对五个不同的癫痫阶段进行了 20 分钟的评估，并测量了包括最大癫痫阶段、第 4 阶段开始的潜伏期、第 4 阶段持续时间和癫痫持续时间在内的参数。不同组在戊四唑注射前或注射后30分钟给予氨水(50和100mg/kg)或其赋形剂。此外，将 D.aminocum (100 mg/kg) 在不同癫痫发作阶段的有效剂量与常见的抗癫痫药苯巴比妥进行了比较。在另一组实验中，我们研究了 D 的有效剂量。在完全点燃的动物身上，通过放置在头骨上的表面电极记录发作间期脑电图。结果表明，在戊四唑注射前后施用氨水，显着降低癫痫发作阶段、癫痫发作持续时间、第 4 阶段持续时间和 1/4 阶段潜伏期。D.aminocum 的抗癫痫作用约为苯巴比妥的 50% 至 60%。此外，当给予完全点燃的动物时，D.aminocum 显着降低癫痫发作阶段、癫痫发作持续时间、第 4 阶段持续时间和 1/4 阶段潜伏期，但对 EEG 子带的功率没有影响。这些结果表明 D.aminocum 在癫痫发作的化学点燃模型中具有抗癫痫和抗惊厥作用。