Association of microRNA 17 host gene variant (rs4284505) with susceptibility and severity of systemic lupus erythematosus.,Immunity, Inflammation and Disease

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Association of microRNA 17 host gene variant (rs4284505) with susceptibility and severity of systemic lupus erythematosus.
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-08-27 , DOI: 10.1002/iid3.344
Abdelhady R Abdel-Gawad ₁ , Sameerah Shaheen ₂ , Nouf A Babteen ₃ , Eman A Toraih _{4,

5} , Rami M Elshazli ₆ , Manal S Fawzy _{7,

8} , Nawal S Gouda _{9,

10}

Affiliation

Department of Clinical and Chemical Pathology, Sohag University, Sohag, Egypt.
Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana.
Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Biochemistry, Faculty of Physical Therapy, Horus University - Egypt, New Damietta, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Department of Microbiology, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.

MicroRNAs are large family clusters of small noncoding RNAs that implicated in genetic and epigenetic regulation of several immunological processes and pathways. As an epigenetic modifier, the microRNA 17‐92 cluster host gene (MIR17HG) has been shown to regulate the expression of genes involved in systemic lupus erythematosus (SLE) pathway. This study aimed to explore the association of MIR17HG (rs4284505; A>G) variant with SLE development and phenotype in a sample of the Eastern Mediterranean population.

中文翻译：

microRNA 17 宿主基因变异 (rs4284505) 与系统性红斑狼疮的易感性和严重程度的关联。

MicroRNA 是小型非编码 RNA 的大家族簇，涉及几种免疫过程和途径的遗传和表观遗传调控。作为表观遗传修饰剂，microRNA 17-92 簇宿主基因 (MIR17HG) 已被证明可调节参与系统性红斑狼疮 (SLE) 通路的基因的表达。本研究旨在探索东地中海人群样本中 MIR17HG（rs4284505；A>G）变异与 SLE 发展和表型的关联。

更新日期：2020-08-27

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