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Adult brain activation in response to pain is changed by neonatal painful stimulation according to sex: A manganese‐enhanced MRI study
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-08-27 , DOI: 10.1111/ejn.14948 Jackeline M. Malheiros 1 , Mariane B. Andreeta 2 , Roberson S. Polli 3 , Fernando F. Paiva 4 , Alberto Tannús 4 , Ruth Guinsburg 5 , Luciene Covolan 1
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-08-27 , DOI: 10.1111/ejn.14948 Jackeline M. Malheiros 1 , Mariane B. Andreeta 2 , Roberson S. Polli 3 , Fernando F. Paiva 4 , Alberto Tannús 4 , Ruth Guinsburg 5 , Luciene Covolan 1
Affiliation
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Although it is known that nociceptive stimulation in the first postnatal week in rats is useful to model preterm pain, resulting in activation of specific brain areas, as assessed in vivo using manganese‐enhanced magnetic resonance imaging (MEMRI), little is known about its long‐term effects and sex specificity. Here we aimed to investigate whether inflammatory pain induced in male and female adult rats modify the pattern of brain activation between animals subjected or not to neonatal pain. For this, Complete Freund's adjuvant (CFA) was injected into the left hind paw of rat pups on postnatal day 1 (P1) or P8 to induce inflammatory response. During adulthood, CFA‐treated and control animals were injected with CFA 1 hr prior MRI. MEMRI has the ability to enhance the contrast of selective brain structures in response to a specific stimulus, as the pain. MEMRI responses were consistent with activation of nociceptive pathways and these responses were reduced in animals treated with CFA on P1, but increased in animals treated on P8, mainly in the female group. In agreement, P8 female group showed exacerbated responses in the thermal nociceptive test. Using MEMRI, we conclude that the natural ability of adult rats to recognize and react to pain exposition is modified by neonatal painful exposition, mainly among females.
中文翻译：
新生儿疼痛刺激会根据性别改变成年人对疼痛的反应：一项锰增强的MRI研究
尽管众所周知，大鼠出生后第一周的伤害性刺激可用于建模早产疼痛，从而导致特定的大脑区域激活（如使用锰增强磁共振成像（MEMRI）在体内进行的评估），但其持续时间却鲜为人知长期影响和性别特异性。在这里，我们旨在调查在成年雄性和雌性成年大鼠中诱发的炎症性疼痛是否会改变动物是否遭受新生儿疼痛的大脑激活模式。为此，在出生后第1天（P1）或P8将完全弗氏佐剂（CFA）注入大鼠幼仔的左后爪，以引起炎症反应。在成年期间，在MRI之前1小时，将CFA治疗和对照动物注射CFA。MEMRI能够根据特定刺激增强选择性脑结构的对比度，作为痛苦。MEMRI反应与伤害性信号通路的激活一致，并且在P1接受CFA治疗的动物中这些反应减少，但在P8治疗的动物中主要在雌性组中增加。一致的是，P8女性组在热伤害感受测试中显示出加剧的反应。使用MEMRI，我们得出结论，成年大鼠识别疼痛反应并对疼痛反应做出反应的自然能力被新生儿疼痛暴露（主要在雌性动物中）改变。
更新日期：2020-08-27
中文翻译：
新生儿疼痛刺激会根据性别改变成年人对疼痛的反应：一项锰增强的MRI研究
尽管众所周知，大鼠出生后第一周的伤害性刺激可用于建模早产疼痛，从而导致特定的大脑区域激活（如使用锰增强磁共振成像（MEMRI）在体内进行的评估），但其持续时间却鲜为人知长期影响和性别特异性。在这里，我们旨在调查在成年雄性和雌性成年大鼠中诱发的炎症性疼痛是否会改变动物是否遭受新生儿疼痛的大脑激活模式。为此，在出生后第1天（P1）或P8将完全弗氏佐剂（CFA）注入大鼠幼仔的左后爪，以引起炎症反应。在成年期间，在MRI之前1小时，将CFA治疗和对照动物注射CFA。MEMRI能够根据特定刺激增强选择性脑结构的对比度，作为痛苦。MEMRI反应与伤害性信号通路的激活一致，并且在P1接受CFA治疗的动物中这些反应减少，但在P8治疗的动物中主要在雌性组中增加。一致的是，P8女性组在热伤害感受测试中显示出加剧的反应。使用MEMRI，我们得出结论，成年大鼠识别疼痛反应并对疼痛反应做出反应的自然能力被新生儿疼痛暴露（主要在雌性动物中）改变。
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