The microphthalmia‐associated transcription factor (MITF) is at the core of melanocyte and melanoma fate specification. The related factors TFEB and TFE3 have been shown to be instrumental for transcriptional regulation of genes involved in lysosome biogenesis and autophagy, cellular processes important for mediating nutrition signals and recycling of cellular materials, in many cell types. The MITF, TFEB, TFE3, and TFEC proteins are highly related. They share many structural and functional features and are targeted by the same signaling pathways. However, the existence of several isoforms of each factor and the increasing number of residues shown to be post‐translationally modified by various signaling pathways poses a difficulty in indexing amino acid residues in different isoforms across the different proteins. Here, we provide a resource manual to cross‐reference amino acids and post‐translational modifications in all isoforms of the MiT‐TFE family in humans, mice, and zebrafish and summarize the protein accession numbers for each isoform of these factors in the different genomic databases. This will facilitate future studies on the signaling pathways that regulate different isoforms of the MiT‐TFE transcription factor family.

中文翻译：

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MiT-TFE 异构体和翻译后修饰的用户指南。

小眼相关转录因子 (MITF) 是黑色素细胞和黑色素瘤命运规范的核心。相关因子 TFEB 和 TFE3 已被证明有助于参与溶酶体生物发生和自噬的基因的转录调节，在许多细胞类型中，这些细胞过程对介导营养信号和细胞材料的回收很重要。MITF、TFEB、TFE3 和 TFEC 蛋白高度相关。它们共享许多结构和功能特征，并以相同的信号通路为目标。然而，每个因子的几种同种型的存在以及越来越多的残基显示被各种信号通路进行翻译后修饰，这给不同蛋白质的不同同种型中的氨基酸残基索引带来了困难。这里，我们提供了一份资源手册，用于交叉参考人类、小鼠和斑马鱼 MiT-TFE 家族所有同种型中的氨基酸和翻译后修饰，并总结了不同基因组数据库中这些因子的每种同种型的蛋白质登录号。这将有助于未来对调节 MiT-TFE 转录因子家族不同亚型的信号通路的研究。