Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct size, while the fate of tumor cells depend on the outcome of their interaction with the immune system and peripheral tissues. In this review, we outline recent studies in Drosophila, which have enabled an improved understanding of the complex crosstalk between organs in the context of both organismal and tumor growth. We argue that Drosophila is a powerful model organism for studying these interactions, and these studies have the potential for improving our understanding of signaling pathways and candidate factors that mediate this conserved interorgan crosstalk.

中文翻译：

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发育和癌症中的器官间交流

对模型生物的研究表明，在发育过程中和癌症等疾病中，远处器官之间会发生广泛的交流。器官相互通信以协调生长并达到正确的大小，而肿瘤细胞的命运取决于它们与免疫系统和外周组织相互作用的结果。在这篇综述中，我们概述了最近在果蝇中的研究，这些研究有助于更好地理解在生物体和肿瘤生长背景下器官之间复杂的串扰。我们认为果蝇 是研究这些相互作用的强大模式生物，这些研究有可能提高我们对介导这种保守的器官间串扰的信号通路和候选因子的理解。