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Sustainable, Site-Specific Linkage of Antimicrobial Peptides to Cotton Textiles.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-08-27 , DOI: 10.1002/mabi.202000199 Stefano Scapin 1 , Fernando Formaggio 1 , Antonella Glisenti 1 , Barbara Biondi 2 , Marco Scocchi 3 , Monica Benincasa 3 , Cristina Peggion 1
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-08-27 , DOI: 10.1002/mabi.202000199 Stefano Scapin 1 , Fernando Formaggio 1 , Antonella Glisenti 1 , Barbara Biondi 2 , Marco Scocchi 3 , Monica Benincasa 3 , Cristina Peggion 1
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A new general method to covalently link a peptide to cotton via thiazolidine ring formation is developed. Three different analogues of an ultrashort antibacterial peptide are synthesized to create an antibacterial fabric. The chemical ligation approach to the heterogeneous phase made up of insoluble cellulose fibers and a peptide solution in water is adapted. The selective click reaction occurs between an N‐terminal cysteine on the peptide and an aldehyde on the cotton matrix. The aldehyde is generated on the primary alcohol of glucose by means of the enzyme laccase and the cocatalyst 2,2,6,6‐tetramethylpiperidine‐1‐oxyl. This keeps the pyranose rings intact and may bring a benefit to the mechanical properties of the fabric. The presence of the peptide on cotton is demonstrated through instant colorimetric tests, UV spectroscopy, IR spectroscopy, and X‐ray photoelectron spectroscopy analysis. The antibacterial activity of the peptides is maintained even after their covalent attachment to cotton fibers.
中文翻译：
抗菌肽与棉纺织品的可持续、特定地点的联系。
开发了一种通过噻唑烷环形成将肽与棉花共价连接的新通用方法。合成了三种不同的超短抗菌肽类似物以制造抗菌织物。对由不溶性纤维素纤维和水中的肽溶液组成的异相的化学连接方法进行了调整。选择性点击反应发生在肽上的 N 端半胱氨酸和棉花基质上的醛之间。醛是通过漆酶酶和助催化剂 2,2,6,6-四甲基哌啶-1-氧基在葡萄糖的伯醇上生成的。这使吡喃糖环保持完整，并可能对织物的机械性能带来好处。通过即时比色测试、紫外光谱、红外光谱、和 X 射线光电子能谱分析。即使在它们与棉纤维共价连接后，肽的抗菌活性仍能保持。
更新日期：2020-08-27
中文翻译：
抗菌肽与棉纺织品的可持续、特定地点的联系。
开发了一种通过噻唑烷环形成将肽与棉花共价连接的新通用方法。合成了三种不同的超短抗菌肽类似物以制造抗菌织物。对由不溶性纤维素纤维和水中的肽溶液组成的异相的化学连接方法进行了调整。选择性点击反应发生在肽上的 N 端半胱氨酸和棉花基质上的醛之间。醛是通过漆酶酶和助催化剂 2,2,6,6-四甲基哌啶-1-氧基在葡萄糖的伯醇上生成的。这使吡喃糖环保持完整，并可能对织物的机械性能带来好处。通过即时比色测试、紫外光谱、红外光谱、和 X 射线光电子能谱分析。即使在它们与棉纤维共价连接后，肽的抗菌活性仍能保持。
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