γδ T cells are found in highest numbers at barrier surfaces throughout the body, including the skin, intestine, lung, gingiva, and uterus. Under homeostatic conditions, γδ T cells provide immune surveillance of the epidermis, intestinal, and oral mucosa, whereas the presence of pathogenic microorganisms in the dermis or lungs elicits a robust γδ17 response to clear the infection. Although T cell migration is most frequently defined in the context of trafficking, analysis of specific migratory behaviors of lymphocytes within the tissue microenvironment can provide valuable insight into their function. Intravital imaging and computational analyses have been used to define “search” behavior associated with conventional αβ T cells; however, based on the known role of γδ T cells as immune sentinels at barrier surfaces and their TCR‐independent functions, we put forth the need to classify distinct migratory patterns that reflect the surveillance capacity of these unconventional lymphocytes. This review will focus on how γδ T cells traffic to various barrier surfaces and how recent investigation into their migratory behavior has provided unique insight into the contribution of γδ T cells to barrier immunity.

中文翻译：

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γδ T 细胞迁移：将贩运与屏障表面的监视行为分开。

γδ T 细胞在全身的屏障表面数量最多，包括皮肤、肠、肺、牙龈和子宫。在稳态条件下，γδ T 细胞对表皮、肠道和口腔粘膜提供免疫监视，而真皮或肺部中病原微生物的存在会引发强烈的 γδ17 反应以清除感染。尽管 T 细胞迁移最常在运输背景下定义，但对组织微环境中淋巴细胞的特定迁移行为的分析可以提供对其功能的有价值的见解。活体成像和计算分析已被用来定义与传统 αβ T 细胞相关的“搜索”行为；然而，基于 γδ T 细胞作为屏障表面免疫哨兵的已知作用及其与 TCR 无关的功能，我们提出需要对反映这些非常规淋巴细胞监视能力的不同迁移模式进行分类。本综述将重点关注 γδ T 细胞如何运输到各种屏障表面，以及最近对其迁移行为的研究如何为 γδ T 细胞对屏障免疫的贡献提供独特的见解。