Animal studies remain essential for understanding mechanisms of epilepsy and identifying new therapeutic targets. However, existing animal models of epilepsy do not reflect the high level of genetic diversity found in the human population. The Collaborative Cross (CC) population is a genetically diverse recombinant inbred panel of mice. The CC offers large genotypic and phenotypic diversity, inbred strains with stable genomes that allow for repeated phenotypic measurements, and genomic tools including whole genome sequence to identify candidate genes and candidate variants.

中文翻译：

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协作杂交小鼠揭示极端癫痫表型和癫痫易感性遗传位点

动物研究对于理解癫痫机制和确定新的治疗靶点仍然至关重要。然而，现有的癫痫动物模型并不能反映人类中发现的高水平遗传多样性。协同杂交 (CC) 种群是一组基因多样的重组近交小鼠。CC 提供大量基因型和表型多样性、具有稳定基因组的近交系，允许重复表型测量，以及包括全基因组序列在内的基因组工具，用于识别候选基因和候选变异。