Direct Introduction of Sulfonamide Groups into Quinoxalin-2(1H)-ones by Cu-Catalyzed C3-H Functionalization.,Chemistry - An Asian Journal

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Direct Introduction of Sulfonamide Groups into Quinoxalin-2(1H)-ones by Cu-Catalyzed C3-H Functionalization.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-08-27 , DOI: 10.1002/asia.202000916
Yushi Tan ₁ , Boyan Liu ₁ , Ya-Ping Han ₁ , Yuecheng Zhang ₁ , Hong-Yu Zhang ₁ , Jiquan Zhao ₁

Affiliation

Direct sulfonamidation of quinoxalin‐2(1H)‐one derivatives has been developed using a readily available Cu salt as the catalyst and inexpensive ammonium persulfate as the oxidant in moderate conditions. Owing to the feature of handy operation and good functional group tolerance, this method provides a convenient and efficient access to curative 3‐sulfonamidated quinoxalin‐2(1H)‐one scaffolds.

中文翻译：

通过铜催化的C3-H官能团将磺酰胺基团直接引入Quinoxalin-2（1H）-ones。

在中等条件下，使用现成的铜盐作为催化剂，廉价的过硫酸铵作为氧化剂，已经开发出喹喔啉-2（1 H）-one衍生物的直接磺酰胺化方法。由于具有操作简便和对官能团的耐受性强的特点，该方法可方便有效地获得治疗性3-磺酰胺化喹喔啉-2（1 H）-one支架。

更新日期：2020-10-17

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