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Light Promoted Synthesis of Quinoxalines and Imidazo[1,2‐a]pyridines via Oxybromination from Alkynes and Alkenes
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-08-26 , DOI: 10.1002/ajoc.202000388
Anupam Das 1 , K. R. Justin Thomas 1
Affiliation  

Light promoted two‐step one‐pot syntheses of quinoxalines and imidazo[1,2‐a]pyridines from alkynes and alkenes, respectively under mild conditions are described. The conversions occur via the formation of α,α′‐dibromo ketones or α‐bromo ketones on irradiation with UV LED fluorescent black light (380–390 nm) in acetonitrile/water mixture. This protocol does not require sensitizer or catalyst or additives. This two‐step protocol is a new entry of synthetic methods available for quinoxaline and imidazopyridine derivatives and offers wide functional group tolerance.

中文翻译:

通过炔烃和烯烃的氧溴化反应光促进喹喔啉和咪唑并[1,2-a]吡啶的合成

描述了在温和条件下分别由炔烃和烯烃光促进的两步一锅合成喹喔啉和咪唑并[1,2-a]吡啶。在乙腈/水混合物中,用UV LED荧光黑光(380-390 nm)照射时,通过形成α,α'-二溴代酮或α-溴代酮来进行转换。该协议不需要敏化剂或催化剂或添加剂。此两步操作规程是可用于喹喔啉和咪唑并吡啶衍生物的合成方法的新条目,并具有宽泛的官能团耐受性。
更新日期:2020-08-26
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