In view of recent global pandemic the 3-alkynyl substituted 2-chloroquinoxaline framework has been explored as a potential template for the design of molecules targeting COVID-19. Initial in silico studies of representative compounds to assess their binding affinities via docking into the N-terminal RNA-binding domain (NTD) of N-protein of SARS-CoV-2 prompted further study of these molecules. Thus building of a small library of molecules based on the said template became essential for this purpose. Accordingly, a convenient and environmentally safer method has been developed for the rapid synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives under Cu-catalysis assisted by ultrasound. This simple and straightforward method involved the coupling of 2,3-dichloroquinoxaline with commercially available terminal alkynes in the presence of CuI, PPh₃ and K₂CO₃ in PEG-400. Further in silico studies revealed some remarkable observations and established a virtual SAR (Structure Activity Relationship) within the series. Three compounds appeared as potential agents for further studies.

鉴于最近的全球大流行，已经研究了3-炔基取代的2-氯喹喔啉骨架作为设计靶向COVID-19的分子的潜在模板。代表性化合物的初步计算机模拟研究，旨在通过以下方法评估其结合亲和力对接进入SARS-CoV-2的N蛋白的N末端RNA结合结构域（NTD）促使对这些分子进行进一步研究。因此，为此目的，基于所述模板构建小分子文库变得至关重要。因此，已经开发了在超声辅助的Cu催化下快速合成3-炔基取代的2-氯喹喔啉衍生物的方便且对环境更安全的方法。这种简单而直接的方法涉及在PEG-400中存在CuI，PPh ₃和K ₂ CO ₃的情况下将2，3-二氯喹喔啉与市售的末端炔烃偶联。进一步的计算机研究揭示了一些非凡的发现，并在该系列中建立了一个虚拟SAR（结构活动关系）。出现了三种化合物作为进一步研究的潜在药物。