The Suzuki-Miyaura coupling between 2-chloro-4-aminoquinazolines and arylboronic acids catalyzed by the well-defined N-heterocyclic carbene-PdCl₂-1-methylimidazole complex was performed at room temperature, giving the desired products in good to high yields. Through this methodology, a variety of 2-aryl-4-aminoquinazoline derivatives with potential pharmaceutical activities can be achieved under mild reaction conditions.

中文翻译：

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N-杂环卡宾-Pd（II）-1-甲基咪唑配合物催化2-氯-4-氨基喹唑啉与芳基硼酸的Suzuki-Miyaura偶联

在室温下进行2-氯-4-氨基喹唑啉与芳基硼酸之间的Suzuki-Miyaura偶合反应，该反应由定义明确的N-杂环卡宾-PdCl ₂ -1-甲基咪唑配合物催化，以高至高收率获得所需产物。通过这种方法，可以在温和的反应条件下获得具有潜在药物活性的各种2-芳基-4-氨基喹唑啉衍生物。