The numerous advantages of hydrogel make it possible to apply as dressing. However, it is challenging in designing hydrogels with desired antibacterial activity and enhanced mechanical properties at the same time. Herein, a graphene oxide/rose bengal/polyvinyl alcohol hybrid hydrogel (β-GO/RB/PVA HD) is prepared by freezing and thawing a mixed polyvinyl alcohol (PVA) solution of rose bengal (RB) immobilized with chitosan microspheres (CM) and a modified graphene oxide network (β-GO). The mechanical properties and light-triggered antibacterial activity of hydrogel are systematically evaluated. The β-GO inorganic network interpenetrate into the PVA porous structure, which significantly improves the mechanical properties of hydrogel. The hyperthermia generated by β-GO under 808 nm light irradiation combined with reactive oxygen species (ROS) produced by RB under 550 nm light irradiation give rise to excellent antibacterial activity requiring irradiation for only 10 min as demonstrated by our experiments conducted in vitro and in vivo. Meanwhile, β-GO/RB/PVA HD exhibits outstanding biocompatibility and water-absorbing capacity. More importantly, the hybrid hydrogel can significantly accelerate bacteria-accompanied wound healing. The results demonstrated that the hybrid hydrogel could be a promising wound dressing for preventing bacterial infection.

水凝胶的众多优点使其有可能用作敷料。然而，在设计同时具有所需抗菌活性和增强的机械性能的水凝胶方面具有挑战性。在此，通过将固定有壳聚糖微球（CM）的玫瑰红（RB）的混合聚乙烯醇（PVA）溶液冷冻并解冻，从而制备氧化石墨烯/玫瑰红/聚乙烯醇杂化水凝胶（β-GO/ RB / PVA HD）以及修饰的氧化石墨烯网络（β-GO）。系统评价了水凝胶的机械性能和光触发的抗菌活性。β-GO无机网络渗透到PVA多孔结构中，大大改善了水凝胶的机械性能。体外和体内。同时，β-GO/ RB / PVA HD具有出色的生物相容性和吸水能力。更重要的是，混合水凝胶可以显着促进细菌伴随的伤口愈合。结果表明，杂化水凝胶可以作为预防细菌感染的有前途的伤口敷料。