Many Gram-negative enteric pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC), Salmonella, Shigella, and Yersinia species have evolved strategies to combat host defence mechanisms. Critical bacterial virulence factors, which often include but are not limited to type III secreted effector proteins, are deployed to cooperatively interfere with key host defence pathways. Recent studies in this area have not only contributed to our knowledge of bacterial pathogenesis, but have also shed light on the host pathways that are critical for controlling bacterial infection. In this review, we summarise recent breakthroughs in our understanding of the mechanisms utilised by enteric bacterial pathogens to rewire critical host innate immune responses, including cell death and inflammatory signaling and cell-intrinsic anti-microbial responses such as xenophagy.

许多革兰氏阴性肠道病原体，包括致病性和肠出血性大肠杆菌（EPEC 和 EHEC）、沙门氏菌、志贺氏菌和耶尔森氏菌物种已经进化出对抗宿主防御机制的策略。关键的细菌毒力因子，通常包括但不限于 III 型分泌的效应蛋白，用于协同干扰关键的宿主防御途径。该领域的最新研究不仅有助于我们了解细菌发病机制，而且还阐明了对控制细菌感染至关重要的宿主途径。在这篇综述中，我们总结了我们对肠道细菌病原体用于重新连接关键宿主先天免疫反应的机制的理解的最新突破，包括细胞死亡和炎症信号传导以及细胞内在抗微生物反应，如异种吞噬。