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Structural organization of the praxis network predicts gesture production: Evidence from healthy subjects and patients with schizophrenia
Cortex ( IF 3.6 ) Pub Date : 2020-08-27 , DOI: 10.1016/j.cortex.2020.05.023
Petra V Viher 1 , Ahmed Abdulkadir 2 , Peter Savadijev 3 , Katharina Stegmayer 4 , Marek Kubicki 5 , Nikos Makris 6 , Sarina Karmacharya 7 , Andrea Federspiel 4 , Stephan Bohlhalter 8 , Tim Vanbellingen 9 , René Müri 10 , Roland Wiest 11 , Werner Strik 4 , Sebastian Walther 4
Affiliation  

Hand gestures are an integral part of social interactions and communication. Several imaging studies in healthy subjects and lesion studies in patients with apraxia suggest the praxis network for gesture production, involving mainly left inferior frontal, posterior parietal and temporal regions. However, little is known about the structural connectivity underlying gesture production. We recruited 41 healthy participants and 39 patients with schizophrenia. All participants performed a gesture production test, the Test of Upper Limb Apraxia, and underwent diffusion tensor imaging. We hypothesized that gesture production is associated with structural network connectivity as well as with tract integrity. We defined the praxis network as an undirected graph comprised of 13 bilateral regions of interest and derived measures of local and global structural connectivity and tract integrity from Finsler geometry. We found an association of gesture deficit with reduced global and local efficiency of the praxis network. Furthermore, reduced tract integrity, for example in the superior longitudinal fascicle, arcuate fascicle or corpus callosum were related to gesture deficits. Our findings contribute to the understanding of structural correlates of gesture production as they first present diffusion tensor imaging data in a combined sample of healthy subjects and a patient cohort with gestural deficits.



中文翻译:

实践网络的结构组织可预测手势产生:来自健康受试者和精神分裂症患者的证据

手势是社交互动和交流中不可或缺的一部分。几项健康受试者的影像学研究和失用症患者的病变研究表明,手势产生的实践网络主要涉及左下额叶,顶叶后壁和颞叶区域。但是,关于手势产生基础的结构连接性知之甚少。我们招募了41位健康参与者和39位精神分裂症患者。所有参与者进行了手势产生测试,即上肢肢体失用测试,并进行了弥散张量成像。我们假设手势的产生与结构网络的连通性以及区域完整性有关。我们将实践网络定义为一个无向图,该图由13个感兴趣的双边区域以及由Finsler几何得出的局部和全局结构连接性以及区域完整性的度量组成。我们发现手势缺陷与降低实践网络的全局和局部效率相关。此外,例如在上纵向束,弓形束或体中的束完整性降低与姿势缺陷有关。我们的发现有助于理解手势产生的结构相关性,因为他们首先在健康受试者和患有手势缺陷的患者队列的组合样本中呈现扩散张量成像数据。我们发现手势缺陷与实践网络的整体和局部效率降低相关。此外,例如在上纵向束,弓形束或体中的束完整性降低与姿势缺陷有关。我们的发现有助于理解手势产生的结构相关性,因为他们首先在健康受试者和患有手势缺陷的患者队列的组合样本中呈现扩散张量成像数据。我们发现手势缺陷与实践网络的整体和局部效率降低相关。此外,例如在上纵向束,弓形束或体中的束完整性降低与姿势缺陷有关。我们的发现有助于理解手势产生的结构相关性,因为他们首先在健康受试者和患有手势缺陷的患者队列的组合样本中呈现扩散张量成像数据。

更新日期:2020-10-02
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