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Bone-targeting polymer vesicles for simultaneous imaging and effective malignant bone tumor treatment
Biomaterials ( IF 12.8 ) Pub Date : 2020-08-27 , DOI: 10.1016/j.biomaterials.2020.120345
Xue Zhou , Ning Yan , Erik J. Cornel , Haidong Cai , Shaobo Xue , Hao Xi , Zhen Fan , Shisheng He , Jianzhong Du

We present a bone-targeting polymer vesicle with excellent single photon emission computed tomography/computed tomography (SPECT/CT) imaging capabilities and high antitumor drug delivery efficiencies as an integrated platform for the simultaneous diagnosing and treatment of malignant bone tumors. This polymer vesicle is self-assembled from poly(ε-caprolactone)67-b-poly[(l-glutamic acid)6-stat-(l-glutamic acid-alendronic acid)16] (PCL67-b-P[Glu6-stat-(Glu-ADA)16]) directly in water without the aid of a cosolvent. SPECT/CT dynamically tracked the drug distribution in the bone tumor rabbit models, and the tumor size was significantly reduced from >2.0 cm3 to <0.6 cm3 over 11 days. The pathological analysis demonstrated obvious necrosis and apoptosis of the tumor cells. Overall, this bone-targeting polymer vesicle provides us with a new platform for the combination of real-time diagnosis and therapy of malignant bone tumors.



中文翻译:

骨靶向聚合物囊泡可同时进行成像和有效的恶性骨肿瘤治疗

我们提出具有出色的单光子发射计算机断层扫描/计算机断层扫描(SPECT / CT)成像功能和高抗肿瘤药物传递效率的骨靶向聚合物囊泡,作为同时诊断和治疗恶性骨肿瘤的综合平台。该聚合物囊泡是由聚(ε-己内酯)67 - b-聚[(l-谷氨酸)6 - stat-l-谷氨酸-alendronic acid)16 ](PCL 67 - b -P [Glu 6 - stat-(Glu-ADA)16])直接在水中,无需助溶剂。SPECT / CT动态跟踪了骨肿瘤兔模型中的药物分布,并且在11天中,肿瘤大小从> 2.0 cm 3显着减小到<0.6 cm 3。病理分析表明肿瘤细胞明显坏死和凋亡。总体而言,这种靶向骨的聚合物囊泡为我们提供了实时诊断和治疗恶性骨肿瘤的新平台。

更新日期:2020-08-27
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