A straight forward synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones (also called azlactones) by the condensation of arylaldehyde with hippuric acid in the presence of acetic anhydride and zinc dust as aheterogeneous catalyst is described. The reaction proceeds rapidly, does not require any additives and has a significantly shorter reaction rate. In the present method, aromatic aldehydes and hippuric acid have been successfully applied to synthesize various substituted azlactones in good to excellent yields. The final product has been characterised by FT-IR, ¹H and ¹³C NMR, and mass spectrometry.

中文翻译：

---

锌粉催化4-亚芳基-2-苯基-5（4H）-恶唑酮的有效合成

描述了在芳族乙醛和锌粉作为非均相催化剂存在下，芳基醛与马尿酸缩合，直接合成4-亚芳基-2-苯基-5（4 H）-恶唑酮（也称为a内酯）的方法。该反应进行迅速，不需要任何添加剂，并且反应速度明显缩短。在本方法中，芳香醛和马尿酸已成功地用于以良好至优异的产率合成各种取代的氮杂内酯。最终产物已通过FT-IR，¹ H和¹³ C NMR以及质谱进行了表征。