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Tandem Prins cyclizations for the construction of oxygen containing heterocycles.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-08-26 , DOI: 10.1039/d0ob00960a P Padmaja 1 , P Narayana Reddy , B V Subba Reddy
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-08-26 , DOI: 10.1039/d0ob00960a P Padmaja 1 , P Narayana Reddy , B V Subba Reddy
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Tandem Prins cyclization is a versatile method for the synthesis of fused/bridged/spirotetrahydropyran scaffolds. Therefore, it has become a powerful tool for the stereoselective synthesis of oxygen/nitrogen containing heterocycles. Indeed, previous review articles on Prins spirocyclization illustrate the synthesis of spirotetrahydropyran derivatives and the aza-Prins reaction demonstrates its application in the total synthesis of natural products. The current review is devoted specifically to highlight tandem Prins cyclizations for the construction of fused scaffolds and related frameworks with a particular emphasis on recent applications. The mechanistic aspects and the scope of the methods are briefly discussed herein.
中文翻译：
Tandem Prins 环化用于构建含氧杂环。
Tandem Prins 环化是一种合成融合/桥接/螺四氢吡喃支架的通用方法。因此，它已成为立体选择性合成含氧/氮杂环的有力工具。事实上，之前关于 Prins 螺环化的评论文章说明了螺四氢吡喃衍生物的合成，而氮杂-Prins 反应证明了其在天然产物全合成中的应用。目前的审查专门强调用于构建融合支架和相关框架的串联 Prins 环化，特别强调最近的应用。本文简要讨论了方法的机制方面和范围。
更新日期：2020-10-07
中文翻译：
Tandem Prins 环化用于构建含氧杂环。
Tandem Prins 环化是一种合成融合/桥接/螺四氢吡喃支架的通用方法。因此，它已成为立体选择性合成含氧/氮杂环的有力工具。事实上，之前关于 Prins 螺环化的评论文章说明了螺四氢吡喃衍生物的合成，而氮杂-Prins 反应证明了其在天然产物全合成中的应用。目前的审查专门强调用于构建融合支架和相关框架的串联 Prins 环化，特别强调最近的应用。本文简要讨论了方法的机制方面和范围。
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