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Hybrid nanoparticle based fluorescence switch for recognition of ketoprofen in aqueous media
Molecular Systems Design & Engineering ( IF 3.2 ) Pub Date : 2020-08-26 , DOI: 10.1039/d0me00065e Anu Saini 1, 2, 3, 4 , Manpreet Kaur 2, 3, 4, 5 , Mayank 4, 5, 6, 7 , Anil Kuwar 4, 8, 9, 10 , Navneet Kaur 1, 2, 3, 4, 5 , Narinder Singh 4, 5, 6, 7
Molecular Systems Design & Engineering ( IF 3.2 ) Pub Date : 2020-08-26 , DOI: 10.1039/d0me00065e Anu Saini 1, 2, 3, 4 , Manpreet Kaur 2, 3, 4, 5 , Mayank 4, 5, 6, 7 , Anil Kuwar 4, 8, 9, 10 , Navneet Kaur 1, 2, 3, 4, 5 , Narinder Singh 4, 5, 6, 7
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A rapid fluorescence method has been developed which describes the sensitive and selective determination of ketoprofen by developing hybrid assemblies composed of silver nanoparticles and organic nanoparticles. Three different ligands were synthesized using various thiourea derivatives and these were processed with organic nanoparticles using a single step re-precipitation method. Hybrid nanoassemblies were developed and consisted of silver nanoparticles and organic nanoparticles, respectively. These were further analysed for their response to various drug molecules and their fluorescence emission spectra were recorded. A non-selective response was observed for hybrid nanoassemblies composed of ethyl isothiocyanate and phenyl isothiocyanate. However, a turn-on fluorescence response to ketoprofen was noticed for the hybrid nanoassembly composed of 1-naphthyl isothiocyanate. Titrations were carried out revealing that with subsequent addition of ketoprofen, a gradual increase in fluorescence emission was noticed. Our sensor can effectively determine ketoprofen up to a detection limit of 34 nM. Moreover, other drug molecules were found to have negligible interference in the sensing of ketoprofen in aqueous media.
中文翻译：
基于混合纳米粒子的荧光开关，用于识别水性介质中的酮洛芬
已经开发出一种快速荧光方法，该方法描述了通过开发由银纳米颗粒和有机纳米颗粒组成的混合组件灵敏和选择性地测定酮洛芬的方法。使用各种硫脲衍生物合成了三种不同的配体，并使用一步重新沉淀法将其与有机纳米颗粒一起加工。开发了混合纳米组件，其分别由银纳米颗粒和有机纳米颗粒组成。进一步分析它们对各种药物分子的反应，并记录其荧光发射光谱。对于由异硫氰酸乙酯和异硫氰酸苯酯组成的杂化纳米组件，观察到非选择性响应。然而，对于由1-萘基异硫氰酸酯组成的杂化纳米组件，发现了对酮洛芬的开启荧光响应。进行滴定表明，随后加入酮洛芬，发现荧光发射逐渐增加。我们的传感器可以有效地测定酮洛芬，最高检出限为34 nM。此外，发现其他药物分子在水性介质中对酮洛芬的感测中的干扰可忽略不计。
更新日期：2020-09-28
中文翻译：
基于混合纳米粒子的荧光开关，用于识别水性介质中的酮洛芬
已经开发出一种快速荧光方法，该方法描述了通过开发由银纳米颗粒和有机纳米颗粒组成的混合组件灵敏和选择性地测定酮洛芬的方法。使用各种硫脲衍生物合成了三种不同的配体，并使用一步重新沉淀法将其与有机纳米颗粒一起加工。开发了混合纳米组件，其分别由银纳米颗粒和有机纳米颗粒组成。进一步分析它们对各种药物分子的反应，并记录其荧光发射光谱。对于由异硫氰酸乙酯和异硫氰酸苯酯组成的杂化纳米组件，观察到非选择性响应。然而，对于由1-萘基异硫氰酸酯组成的杂化纳米组件，发现了对酮洛芬的开启荧光响应。进行滴定表明，随后加入酮洛芬，发现荧光发射逐渐增加。我们的传感器可以有效地测定酮洛芬，最高检出限为34 nM。此外，发现其他药物分子在水性介质中对酮洛芬的感测中的干扰可忽略不计。
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